BRD-K10882151_BO2 (inhibits RAD51)_U937_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_U937_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACAA2 acetyl-CoA acyltransferase 2
ACKR3 atypical chemokine receptor 3
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP9 aquaporin 9
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF132 chromosome 14 open reading frame 132
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CFD complement factor D (adipsin)
CLU clusterin
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMXL2 Dmx-like 2
DUSP1 dual specificity phosphatase 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ETNPPL ethanolamine-phosphate phospho-lyase
FAM46A family with sequence similarity 46, member A
FGFR1 fibroblast growth factor receptor 1
FTH1 ferritin, heavy polypeptide 1
GRN granulin
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IL1R2 interleukin 1 receptor, type II
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
NAP1L3 nucleosome assembly protein 1-like 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOVA1 neuro-oncological ventral antigen 1
NRIP1 nuclear receptor interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLBD1 phospholipase B domain containing 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN2 perilipin 2
PRKCI protein kinase C, iota
PSAP prosaposin
QDPR quinoid dihydropteridine reductase
RAB21 RAB21, member RAS oncogene family
RGS5 regulator of G-protein signaling 5
SAP30 Sin3A-associated protein, 30kDa
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPAG5 sperm associated antigen 5
SPATA7 spermatogenesis associated 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYT1 synaptotagmin I
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR4 toll-like receptor 4
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TYROBP TYRO protein tyrosine kinase binding protein
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WSB1 WD repeat and SOCS box containing 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
BAMBI BMP and activin membrane-bound inhibitor
C1ORF116 chromosome 1 open reading frame 116
C3 complement component 3
CCDC86 coiled-coil domain containing 86
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL21 chemokine (C-C motif) ligand 21
CCND3 cyclin D3
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CD69 CD69 molecule
CDC25A cell division cycle 25A
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CTPS1 CTP synthase 1
CTSH cathepsin H
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DPH2 DPH2 homolog (S. cerevisiae)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
EXOSC4 exosome component 4
FAM3C family with sequence similarity 3, member C
FBLN1 fibulin 1
FCMR Fc fragment of IgM receptor
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GDF15 growth differentiation factor 15
GNAS GNAS complex locus
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GOLM1 golgi membrane protein 1
GTPBP4 GTP binding protein 4
HBEGF heparin-binding EGF-like growth factor
HHEX hematopoietically expressed homeobox
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGHM immunoglobulin heavy constant mu
KRT15 keratin 15, type I
KRT23 keratin 23, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LINC00341 long intergenic non-protein coding RNA 341
LPL lipoprotein lipase
LRRC59 leucine rich repeat containing 59
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MOXD1 monooxygenase, DBH-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NNMT nicotinamide N-methyltransferase
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NUP85 nucleoporin 85kDa
PANK3 pantothenate kinase 3
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
POU2AF1 POU class 2 associating factor 1
PPIF peptidylprolyl isomerase F
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRAME preferentially expressed antigen in melanoma
RAB38 RAB38, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPIA ribose 5-phosphate isomerase A
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPEN spen family transcriptional repressor
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCF4 transcription factor 4
TFB2M transcription factor B2, mitochondrial
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM87A transmembrane protein 87A
TNC tenascin C
UGCG UDP-glucose ceramide glucosyltransferase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZDHHC6 zinc finger, DHHC-type containing 6
Funding