BRD-K10882151_BO2 (inhibits RAD51)_VCAP_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_VCAP_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CP ceruloplasmin (ferroxidase)
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LBH limb bud and heart development
MARCKS myristoylated alanine-rich protein kinase C substrate
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
P3H2 prolyl 3-hydroxylase 2
PFN2 profilin 2
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPAP2B phosphatidic acid phosphatase type 2B
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
TGFBI transforming growth factor, beta-induced, 68kDa
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TXNRD1 thioredoxin reductase 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADI1 acireductone dioxygenase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
B3GNT1
CAPN3 calpain 3, (p94)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EXOSC4 exosome component 4
F3 coagulation factor III (thromboplastin, tissue factor)
FAM107A family with sequence similarity 107, member A
FERMT1 fermitin family member 1
GPM6B glycoprotein M6B
GPX1 glutathione peroxidase 1
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP7 insulin-like growth factor binding protein 7
LAMA3 laminin, alpha 3
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAB21L2 mab-21-like 2 (C. elegans)
MAPT microtubule-associated protein tau
MREG melanoregulin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1X metallothionein 1X
PALLD palladin, cytoskeletal associated protein
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
SCGB2A1 secretoglobin, family 2A, member 1
SFRP1 secreted frizzled-related protein 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
ST7 suppression of tumorigenicity 7
TIMP3 TIMP metallopeptidase inhibitor 3
UBE3A ubiquitin protein ligase E3A
Funding