BRD-K10995081_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K10995081_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK AHNAK nucleoprotein
ARMCX3 armadillo repeat containing, X-linked 3
BAG3 BCL2-associated athanogene 3
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DHCR7 7-dehydrocholesterol reductase
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DSP desmoplakin
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO3 forkhead box O3
FSCN1 fascin actin-bundling protein 1
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LGMN legumain
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MSMO1 methylsterol monooxygenase 1
OPTN optineurin
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHYH phytanoyl-CoA 2-hydroxylase
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TARS threonyl-tRNA synthetase
TFF1 trefoil factor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN13 tetraspanin 13
VCAN versican
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ACTG2 actin, gamma 2, smooth muscle, enteric
ALOX5 arachidonate 5-lipoxygenase
AQP1 aquaporin 1 (Colton blood group)
CA2 carbonic anhydrase II
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DIXDC1 DIX domain containing 1
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
HOPX HOP homeobox
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
JAM3 junctional adhesion molecule 3
KRT13 keratin 13, type I
LRRC17 leucine rich repeat containing 17
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
PCP4 Purkinje cell protein 4
PEG3 paternally expressed 3
PLBD1 phospholipase B domain containing 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGIS prostaglandin I2 (prostacyclin) synthase
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RNF167 ring finger protein 167
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
TRIB2 tribbles pseudokinase 2
WNT5A wingless-type MMTV integration site family, member 5A
Funding