BRD-K11671649_5-amino-1-ethyl-3-(naphthalen-1-ylmethyl)-1H-pyrazole-4-carbonitrile CAL-NCGC-061_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K11671649_5-amino-1-ethyl-3-(naphthalen-1-ylmethyl)-1H-pyrazole-4-carbonitrile CAL-NCGC-061_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACSL1 acyl-CoA synthetase long-chain family member 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
AP3S2 adaptor-related protein complex 3, sigma 2 subunit
APOD apolipoprotein D
AREG amphiregulin
C1S complement component 1, s subcomponent
CDK4 cyclin-dependent kinase 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
CRYL1 crystallin, lambda 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP1 cytoplasmic FMR1 interacting protein 1
ELN elastin
F12 coagulation factor XII (Hageman factor)
FAM171A1 family with sequence similarity 171, member A1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IGHMBP2 immunoglobulin mu binding protein 2
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
ITM2A integral membrane protein 2A
KLHL21 kelch-like family member 21
LAMC2 laminin, gamma 2
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LINC00341 long intergenic non-protein coding RNA 341
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NGRN neugrin, neurite outgrowth associated
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDE8A phosphodiesterase 8A
PDGFA platelet-derived growth factor alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RBM6 RNA binding motif protein 6
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPAG4 sperm associated antigen 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TTR transthyretin
TUBB6 tubulin, beta 6 class V
UBL3 ubiquitin-like 3

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACPP acid phosphatase, prostate
ADGRL2 adhesion G protein-coupled receptor L2
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BTG2 BTG family, member 2
CCNG2 cyclin G2
CD24 CD24 molecule
CDK14 cyclin-dependent kinase 14
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CFI complement factor I
CHMP4A charged multivesicular body protein 4A
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COLEC12 collectin sub-family member 12
CPM carboxypeptidase M
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL11 chemokine (C-X-C motif) ligand 11
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
EGFL6 EGF-like-domain, multiple 6
EHF ets homologous factor
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FCHO1 FCH domain only 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FXYD3 FXYD domain containing ion transport regulator 3
FZD5 frizzled class receptor 5
GJA1 gap junction protein, alpha 1, 43kDa
GRB7 growth factor receptor-bound protein 7
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
JCHAIN joining chain of multimeric IgA and IgM
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MXRA5 matrix-remodelling associated 5
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
NPR3 natriuretic peptide receptor 3
NPY1R neuropeptide Y receptor Y1
OPN3 opsin 3
P3H2 prolyl 3-hydroxylase 2
PBX1 pre-B-cell leukemia homeobox 1
PCP4 Purkinje cell protein 4
PDLIM5 PDZ and LIM domain 5
PDZD2 PDZ domain containing 2
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLXNB2 plexin B2
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PRUNE2 prune homolog 2 (Drosophila)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRK protein tyrosine phosphatase, receptor type, K
RTN2 reticulon 2
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
STON1 stonin 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
UBE2J1 ubiquitin-conjugating enzyme E2, J1
USP34 ubiquitin specific peptidase 34
VDAC1 voltage-dependent anion channel 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
Funding