BRD-K11795542_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K11795542_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ANKRD10 ankyrin repeat domain 10
APOA1 apolipoprotein A-I
ARMCX2 armadillo repeat containing, X-linked 2
ASRGL1 asparaginase like 1
BEX1 brain expressed, X-linked 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
GREB1 growth regulation by estrogen in breast cancer 1
GSTM3 glutathione S-transferase mu 3 (brain)
HNMT histamine N-methyltransferase
NT5E 5'-nucleotidase, ecto (CD73)
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG3 paternally expressed 3
PNMAL1 paraneoplastic Ma antigen family-like 1
SCG2 secretogranin II
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
STC1 stanniocalcin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
C1S complement component 1, s subcomponent
CAV2 caveolin 2
CCND2 cyclin D2
CD58 CD58 molecule
CENPU centromere protein U
CXCL12 chemokine (C-X-C motif) ligand 12
DAAM1 dishevelled associated activator of morphogenesis 1
DICER1 dicer 1, ribonuclease type III
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETV1 ets variant 1
FAM129A family with sequence similarity 129, member A
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
IGF1R insulin-like growth factor 1 receptor
IGKV1-5 immunoglobulin kappa variable 1-5
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
MAT2A methionine adenosyltransferase II, alpha
MEPCE methylphosphate capping enzyme
MYO1B myosin IB
NR2F6 nuclear receptor subfamily 2, group F, member 6
PDGFA platelet-derived growth factor alpha polypeptide
PLAGL1 pleiomorphic adenoma gene-like 1
PLK2 polo-like kinase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTGES prostaglandin E synthase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TARP TCR gamma alternate reading frame protein
TCF4 transcription factor 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53BP2 tumor protein p53 binding protein 2
UGCG UDP-glucose ceramide glucosyltransferase
WSB1 WD repeat and SOCS box containing 1
ZNF131 zinc finger protein 131