BRD-K11911061_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K11911061_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COL1A1 collagen, type I, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
EGFL6 EGF-like-domain, multiple 6
ESRP1 epithelial splicing regulatory protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCGBP Fc fragment of IgG binding protein
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
HMOX1 heme oxygenase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
LRRC15 leucine rich repeat containing 15
MAGEA3 melanoma antigen family A3
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MT1F metallothionein 1F
MT1G metallothionein 1G
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NXN nucleoredoxin
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PKP2 plakophilin 2
PLAT plasminogen activator, tissue
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PODXL podocalyxin-like
PSAT1 phosphoserine aminotransferase 1
RCAN1 regulator of calcineurin 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TMPRSS3 transmembrane protease, serine 3
TNNT1 troponin T type 1 (skeletal, slow)
XPO7 exportin 7

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCNF cyclin F
CDC25B cell division cycle 25B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EPHA3 EPH receptor A3
FGF13 fibroblast growth factor 13
FOLR1 folate receptor 1 (adult)
GLUL glutamate-ammonia ligase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
KIF20A kinesin family member 20A
KIF5B kinesin family member 5B
RHOB ras homolog family member B
SERHL2 serine hydrolase-like 2
SYBU syntabulin (syntaxin-interacting)
TBX3 T-box 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM47 transmembrane protein 47
TOP2A topoisomerase (DNA) II alpha 170kDa
TTC3 tetratricopeptide repeat domain 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB20 zinc finger and BTB domain containing 20
Funding