BRD-K11927976_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-K11927976_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APOA1 apolipoprotein A-I
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BLNK B-cell linker
C14ORF132 chromosome 14 open reading frame 132
CAPG capping protein (actin filament), gelsolin-like
CCND2 cyclin D2
CD52 CD52 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CETN2 centrin, EF-hand protein, 2
CLCA1 chloride channel accessory 1
CLEC10A C-type lectin domain family 10, member A
CNN1 calponin 1, basic, smooth muscle
COL11A1 collagen, type XI, alpha 1
CRP C-reactive protein, pentraxin-related
CXCR4 chemokine (C-X-C motif) receptor 4
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNTT DNA nucleotidylexotransferase
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBLN1 fibulin 1
FBN2 fibrillin 2
FILIP1L filamin A interacting protein 1-like
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXG1 forkhead box G1
GAGE3 G antigen 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAS6 growth arrest-specific 6
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IL1RN interleukin 1 receptor antagonist
JUP junction plakoglobin
KCNK12 potassium channel, two pore domain subfamily K, member 12
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
MAGEA3 melanoma antigen family A3
MAOA monoamine oxidase A
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1M metallothionein 1M
NMU neuromedin U
NUPR1 nuclear protein, transcriptional regulator, 1
PKP2 plakophilin 2
PLXNA1 plexin A1
PRSS16 protease, serine, 16 (thymus)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SOX17 SRY (sex determining region Y)-box 17
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK4 serine peptidase inhibitor, Kazal type 4
SULF1 sulfatase 1
TF transferrin
THBS2 thrombospondin 2
TKTL1 transketolase-like 1
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
UBE3B ubiquitin protein ligase E3B
UGP2 UDP-glucose pyrophosphorylase 2
VNN1 vanin 1

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCLAF1 BCL2-associated transcription factor 1
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CDK6 cyclin-dependent kinase 6
CENPB centromere protein B, 80kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CLTA clathrin, light chain A
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EXOSC4 exosome component 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FHL2 four and a half LIM domains 2
FNDC3B fibronectin type III domain containing 3B
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRWD1 glutamate-rich WD repeat containing 1
H1F0 H1 histone family, member 0
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KLHL21 kelch-like family member 21
KRT10 keratin 10, type I
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
MCL1 myeloid cell leukemia 1
MED6 mediator complex subunit 6
MFSD10 major facilitator superfamily domain containing 10
NFIB nuclear factor I/B
NMB neuromedin B
NOP56 NOP56 ribonucleoprotein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POU2AF1 POU class 2 associating factor 1
PPIF peptidylprolyl isomerase F
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PUF60 poly-U binding splicing factor 60KDa
QDPR quinoid dihydropteridine reductase
RAB14 RAB14, member RAS oncogene family
RANBP6 RAN binding protein 6
RBMS1 RNA binding motif, single stranded interacting protein 1
RNF167 ring finger protein 167
RPL38 ribosomal protein L38
RPS5 ribosomal protein S5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SCAND1 SCAN domain containing 1
SERBP1 SERPINE1 mRNA binding protein 1
SLIRP SRA stem-loop interacting RNA binding protein
SNRPE small nuclear ribonucleoprotein polypeptide E
SRSF11 serine/arginine-rich splicing factor 11
SSFA2 sperm specific antigen 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFB2M transcription factor B2, mitochondrial
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNPO1 transportin 1
TXLNA taxilin alpha
URM1 ubiquitin related modifier 1
ZNF512B zinc finger protein 512B