BRD-K12184916_-666_A375_6.0_h_0.63_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K12184916_-666_A375_6.0_h_0.63_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
AMDHD2 amidohydrolase domain containing 2
ANXA4 annexin A4
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF48 chromosome 6 open reading frame 48
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4A2 eukaryotic translation initiation factor 4A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FNTA farnesyltransferase, CAAX box, alpha
GCC2 GRIP and coiled-coil domain containing 2
HBP1 HMG-box transcription factor 1
HOXC6 homeobox C6
IGFBP3 insulin-like growth factor binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KLHDC2 kelch domain containing 2
LETMD1 LETM1 domain containing 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MSLN mesothelin
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NOTCH2NL notch 2 N-terminal like
NRN1 neuritin 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PLAT plasminogen activator, tissue
PNKP polynucleotide kinase 3'-phosphatase
RNMT RNA (guanine-7-) methyltransferase
SFRP4 secreted frizzled-related protein 4
SQSTM1 sequestosome 1
TP53 tumor protein p53
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR45 WD repeat domain 45
YBX3 Y box binding protein 3

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
BAG3 BCL2-associated athanogene 3
CA12 carbonic anhydrase XII
CALU calumenin
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSC cathepsin C
CTSZ cathepsin Z
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5A cytochrome b5 type A (microsomal)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF4A3 eukaryotic translation initiation factor 4A3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP1B FK506 binding protein 1B, 12.6 kDa
GCLM glutamate-cysteine ligase, modifier subunit
GSTA1 glutathione S-transferase alpha 1
HSPA1A heat shock 70kDa protein 1A
IL17RB interleukin 17 receptor B
JUN jun proto-oncogene
KIAA0232 KIAA0232
KRT17 keratin 17, type I
KRT4 keratin 4, type II
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NT5DC2 5'-nucleotidase domain containing 2
PIR pirin (iron-binding nuclear protein)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX1 peroxiredoxin 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SDC2 syndecan 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SMCO4 single-pass membrane protein with coiled-coil domains 4
SRGN serglycin
TM9SF2 transmembrane 9 superfamily member 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)