BRD-K12184916_-666_MCF7_6.0_h_0.63_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K12184916_-666_MCF7_6.0_h_0.63_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
APOD apolipoprotein D
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CD46 CD46 molecule, complement regulatory protein
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CES1 carboxylesterase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL9A2 collagen, type IX, alpha 2
COLEC12 collectin sub-family member 12
CREBL2 cAMP responsive element binding protein-like 2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
EIF4A2 eukaryotic translation initiation factor 4A2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EVI2A ecotropic viral integration site 2A
F11R F11 receptor
FAM63A family with sequence similarity 63, member A
FN1 fibronectin 1
FOXN3 forkhead box N3
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GNS glucosamine (N-acetyl)-6-sulfatase
GRN granulin
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HMGB2 high mobility group box 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP5 insulin-like growth factor binding protein 5
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KDM3A lysine (K)-specific demethylase 3A
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
LITAF lipopolysaccharide-induced TNF factor
LMO3 LIM domain only 3 (rhombotin-like 2)
LRP10 low density lipoprotein receptor-related protein 10
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NBR1 neighbor of BRCA1 gene 1
NDC80 NDC80 kinetochore complex component
NEU1 sialidase 1 (lysosomal sialidase)
NINL ninein-like
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNKP polynucleotide kinase 3'-phosphatase
PNRC1 proline-rich nuclear receptor coactivator 1
PSAP prosaposin
RAB40B RAB40B, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS10 regulator of G-protein signaling 10
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SFRP1 secreted frizzled-related protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STON1 stonin 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TXNIP thioredoxin interacting protein
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
ARPC5L actin related protein 2/3 complex, subunit 5-like
BAG5 BCL2-associated athanogene 5
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBFB core-binding factor, beta subunit
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CSRP2 cysteine and glycine-rich protein 2
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECM1 extracellular matrix protein 1
EIF4E eukaryotic translation initiation factor 4E
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GABPB1 GA binding protein transcription factor, beta subunit 1
GAL galanin/GMAP prepropeptide
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GREM1 gremlin 1, DAN family BMP antagonist
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
JMJD6 jumonji domain containing 6
LSM12 LSM12 homolog (S. cerevisiae)
LTF lactotransferrin
MMP12 matrix metallopeptidase 12
MXRA7 matrix-remodelling associated 7
NOP16 NOP16 nucleolar protein
ODC1 ornithine decarboxylase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFPQ splicing factor proline/glutamine-rich
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SPINK1 serine peptidase inhibitor, Kazal type 1
TFDP1 transcription factor Dp-1
TIPIN TIMELESS interacting protein
TMEM47 transmembrane protein 47
TUBB4B tubulin, beta 4B class IVb
UBE2N ubiquitin-conjugating enzyme E2N
Funding