BRD-K12184916_NVP-BEZ235_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AHR aryl hydrocarbon receptor
AKAP13 A kinase (PRKA) anchor protein 13
BACE2 beta-site APP-cleaving enzyme 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CST1 cystatin SN
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
DUSP1 dual specificity phosphatase 1
ERBB3 erb-b2 receptor tyrosine kinase 3
EVI2A ecotropic viral integration site 2A
FOXN3 forkhead box N3
GABARAPL2 GABA(A) receptor-associated protein-like 2
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HIST1H4J histone cluster 1, H4j
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
ITPKB inositol-trisphosphate 3-kinase B
KLHL24 kelch-like family member 24
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2B1 mannosidase, alpha, class 2B, member 1
MOXD1 monooxygenase, DBH-like 1
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NAV2 neuron navigator 2
NBR1 neighbor of BRCA1 gene 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
PAWR PRKC, apoptosis, WT1, regulator
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RB1CC1 RB1-inducible coiled-coil 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
SYNJ2 synaptojanin 2
TPP1 tripeptidyl peptidase I
TRBC1 T cell receptor beta constant 1
TSPAN4 tetraspanin 4
VAT1 vesicle amine transport 1
YPEL5 yippee-like 5 (Drosophila)
ZHX2 zinc fingers and homeoboxes 2
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC6 cell division cycle 6
CENPU centromere protein U
CKS1B CDC28 protein kinase regulatory subunit 1B
CRLF1 cytokine receptor-like factor 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
DNM1L dynamin 1-like
ENO1 enolase 1, (alpha)
FADS1 fatty acid desaturase 1
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GPI glucose-6-phosphate isomerase
GSTM3 glutathione S-transferase mu 3 (brain)
HOXB6 homeobox B6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS isoleucyl-tRNA synthetase
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0101 KIAA0101
LIMCH1 LIM and calponin homology domains 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
PCNA proliferating cell nuclear antigen
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PON2 paraoxonase 2
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAI14 retinoic acid induced 14
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RFC4 replication factor C (activator 1) 4, 37kDa
SCGB2A2 secretoglobin, family 2A, member 2
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLPI secretory leukocyte peptidase inhibitor
TFRC transferrin receptor
TK1 thymidine kinase 1, soluble
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
Funding