BRD-K12184916_NVP-BEZ235_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

205 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BACE2 beta-site APP-cleaving enzyme 2
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
COBL cordon-bleu WH2 repeat protein
CST1 cystatin SN
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DST dystonin
ERBB3 erb-b2 receptor tyrosine kinase 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM117A family with sequence similarity 117, member A
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GPR137B G protein-coupled receptor 137B
GRN granulin
GSDMB gasdermin B
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HECA headcase homolog (Drosophila)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IL6ST interleukin 6 signal transducer
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSR insulin receptor
KDM3A lysine (K)-specific demethylase 3A
KIAA0430 KIAA0430
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LGALS8 lectin, galactoside-binding, soluble, 8
LMBRD1 LMBR1 domain containing 1
LRP10 low density lipoprotein receptor-related protein 10
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2B1 mannosidase, alpha, class 2B, member 1
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MT1F metallothionein 1F
MXI1 MAX interactor 1, dimerization protein
NBR1 neighbor of BRCA1 gene 1
NEU1 sialidase 1 (lysosomal sialidase)
NPDC1 neural proliferation, differentiation and control, 1
OXTR oxytocin receptor
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLIN2 perilipin 2
PMEL premelanosome protein
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRAME preferentially expressed antigen in melanoma
PSPH phosphoserine phosphatase
QPCT glutaminyl-peptide cyclotransferase
RALGDS ral guanine nucleotide dissociation stimulator
RB1CC1 RB1-inducible coiled-coil 1
REEP5 receptor accessory protein 5
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RNASE4 ribonuclease, RNase A family, 4
RNF103 ring finger protein 103
RPL36 ribosomal protein L36
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SEPP1 selenoprotein P, plasma, 1
SNAP23 synaptosomal-associated protein, 23kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SQSTM1 sequestosome 1
STON1 stonin 1
STXBP2 syntaxin binding protein 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBC1D15 TBC1 domain family, member 15
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGM2 transglutaminase 2
TLE2 transducin-like enhancer of split 2
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TYRP1 tyrosinase-related protein 1
UBE2B ubiquitin-conjugating enzyme E2B
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIN1 bridging integrator 1
BZW2 basic leucine zipper and W2 domains 2
C1QBP complement component 1, q subcomponent binding protein
CACYBP calcyclin binding protein
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CD24 CD24 molecule
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CENPU centromere protein U
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CYB561 cytochrome b561
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
HMGB1 high mobility group box 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGKV1-5 immunoglobulin kappa variable 1-5
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA0101 KIAA0101
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MMP12 matrix metallopeptidase 12
MRPL12 mitochondrial ribosomal protein L12
MRPS16 mitochondrial ribosomal protein S16
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPR3 natriuretic peptide receptor 3
NRIP1 nuclear receptor interacting protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PFN2 profilin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRMT1 protein arginine methyltransferase 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SDF2L1 stromal cell-derived factor 2-like 1
SEH1L SEH1-like (S. cerevisiae)
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC43A3 solute carrier family 43, member 3
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SRM spermidine synthase
TCL1A T-cell leukemia/lymphoma 1A
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WDR77 WD repeat domain 77
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZWINT ZW10 interacting kinetochore protein
Funding