BRD-K12184916_NVP-BEZ235_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

225 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
AMDHD2 amidohydrolase domain containing 2
ANXA1 annexin A1
ANXA4 annexin A4
ARG1 arginase 1
ARL4C ADP-ribosylation factor-like 4C
ATF4 activating transcription factor 4
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP9A ATPase, class II, type 9A
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CALML5 calmodulin-like 5
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CDK19 cyclin-dependent kinase 19
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CTBP1 C-terminal binding protein 1
CTSK cathepsin K
CYBRD1 cytochrome b reductase 1
DDIT3 DNA-damage-inducible transcript 3
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP6 dual specificity phosphatase 6
EIF4B eukaryotic translation initiation factor 4B
EIF5 eukaryotic translation initiation factor 5
FGR FGR proto-oncogene, Src family tyrosine kinase
FOXG1 forkhead box G1
GABARAP GABA(A) receptor-associated protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNPDA1 glucosamine-6-phosphate deaminase 1
GPR137B G protein-coupled receptor 137B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX4 glutathione peroxidase 4
GREM1 gremlin 1, DAN family BMP antagonist
GUSB glucuronidase, beta
H1F0 H1 histone family, member 0
HAUS4 HAUS augmin-like complex, subunit 4
HEBP2 heme binding protein 2
HES1 hes family bHLH transcription factor 1
HIST3H2A histone cluster 3, H2a
HMGA1 high mobility group AT-hook 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGBP1 immunoglobulin (CD79A) binding protein 1
INSR insulin receptor
IRS2 insulin receptor substrate 2
ITGB4 integrin, beta 4
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDSR 3-ketodihydrosphingosine reductase
KYNU kynureninase
LETMD1 LETM1 domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCOLN1 mucolipin 1
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MOXD1 monooxygenase, DBH-like 1
MUM1 melanoma associated antigen (mutated) 1
MZT2A mitotic spindle organizing protein 2A
MZT2B mitotic spindle organizing protein 2B
NONO non-POU domain containing, octamer-binding
NPC1 Niemann-Pick disease, type C1
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
OSBPL1A oxysterol binding protein-like 1A
OXA1L oxidase (cytochrome c) assembly 1-like
PARP6 poly (ADP-ribose) polymerase family, member 6
PGLS 6-phosphogluconolactonase
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G16 phospholipase A2, group XVI
PPAP2C phosphatidic acid phosphatase type 2C
RGCC regulator of cell cycle
RPL36 ribosomal protein L36
S100P S100 calcium binding protein P
SCCPDH saccharopine dehydrogenase (putative)
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC38A2 solute carrier family 38, member 2
SPRY4 sprouty homolog 4 (Drosophila)
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SQSTM1 sequestosome 1
SSFA2 sperm specific antigen 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STX1A syntaxin 1A (brain)
TBC1D15 TBC1 domain family, member 15
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM4SF4 transmembrane 4 L six family member 4
TMC5 transmembrane channel-like 5
TMEM204 transmembrane protein 204
TPP1 tripeptidyl peptidase I
UBXN1 UBX domain protein 1
VAT1 vesicle amine transport 1
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACKR3 atypical chemokine receptor 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
ADRA2A adrenoceptor alpha 2A
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK4 adenylate kinase 4
ALB albumin
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
AQP3 aquaporin 3 (Gill blood group)
ARF4 ADP-ribosylation factor 4
ARG2 arginase 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKAP4 cytoskeleton-associated protein 4
CLIC3 chloride intracellular channel 3
CLU clusterin
CNN3 calponin 3, acidic
COL5A1 collagen, type V, alpha 1
CTSC cathepsin C
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL6 chemokine (C-X-C motif) ligand 6
CYCS cytochrome c, somatic
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EGF epidermal growth factor
ENO1 enolase 1, (alpha)
FABP1 fatty acid binding protein 1, liver
FGL2 fibrinogen-like 2
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GBP1 guanylate binding protein 1, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
GOLM1 golgi membrane protein 1
GPC3 glypican 3
GREB1 growth regulation by estrogen in breast cancer 1
GSTM3 glutathione S-transferase mu 3 (brain)
GYS1 glycogen synthase 1 (muscle)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
HYOU1 hypoxia up-regulated 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
INSIG1 insulin induced gene 1
ITM2C integral membrane protein 2C
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KRT13 keratin 13, type I
KRT18 keratin 18, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LOC100505650 uncharacterized LOC100505650
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
LRRC59 leucine rich repeat containing 59
MAGT1 magnesium transporter 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLEC malectin
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAM1 neural cell adhesion molecule 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NOTCH2 notch 2
NRCAM neuronal cell adhesion molecule
ODC1 ornithine decarboxylase 1
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCP4 Purkinje cell protein 4
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PYCR1 pyrroline-5-carboxylate reductase 1
RHOB ras homolog family member B
SACS sacsin molecular chaperone
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC24D SEC24 family member D
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SQLE squalene epoxidase
SRGN serglycin
SSR1 signal sequence receptor, alpha
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TMED9 transmembrane emp24 protein transport domain containing 9
TNC tenascin C
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TTC39A tetratricopeptide repeat domain 39A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Funding