BRD-K12184916_NVP-BEZ235_HS578T_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_HS578T_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM12 ADAM metallopeptidase domain 12
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADD3 adducin 3 (gamma)
ADGRL2 adhesion G protein-coupled receptor L2
ANGPT1 angiopoietin 1
ATF3 activating transcription factor 3
BAALC brain and acute leukemia, cytoplasmic
BICC1 BicC family RNA binding protein 1
C2CD2 C2 calcium-dependent domain containing 2
CA12 carbonic anhydrase XII
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHEK2 checkpoint kinase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL5A1 collagen, type V, alpha 1
CTGF connective tissue growth factor
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN1 fibrillin 1
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FOXG1 forkhead box G1
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLT1B golgi transport 1B
GPM6B glycoprotein M6B
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
LHX2 LIM homeobox 2
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
METTL7A methyltransferase like 7A
MMD monocyte to macrophage differentiation-associated
NFIB nuclear factor I/B
NOTCH2NL notch 2 N-terminal like
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PEG10 paternally expressed 10
PPAP2B phosphatidic acid phosphatase type 2B
RGS1 regulator of G-protein signaling 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SESN1 sestrin 1
SGCE sarcoglycan, epsilon
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNM synemin, intermediate filament protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TTC3 tetratricopeptide repeat domain 3
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADRB2 adrenoceptor beta 2, surface
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CD3D CD3d molecule, delta (CD3-TCR complex)
CD81 CD81 molecule
CDC25A cell division cycle 25A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTSH cathepsin H
CYB5R2 cytochrome b5 reductase 2
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ESR1 estrogen receptor 1
FOLR1 folate receptor 1 (adult)
FYB FYN binding protein
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IFITM1 interferon induced transmembrane protein 1
IL7R interleukin 7 receptor
ITK IL2-inducible T-cell kinase
LAMA3 laminin, alpha 3
LAMP5 lysosomal-associated membrane protein family, member 5
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MEIS1 Meis homeobox 1
MSMB microseminoprotein, beta-
NR2F6 nuclear receptor subfamily 2, group F, member 6
PCP4 Purkinje cell protein 4
PODXL podocalyxin-like
REEP1 receptor accessory protein 1
RGS5 regulator of G-protein signaling 5
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFTPA2 surfactant protein A2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRPF small nuclear ribonucleoprotein polypeptide F
TMEM30B transmembrane protein 30B
Funding