BRD-K12184916_NVP-BEZ235_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CYTH1 cytohesin 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
FN1 fibronectin 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
JCHAIN joining chain of multimeric IgA and IgM
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
LITAF lipopolysaccharide-induced TNF factor
LXN latexin
MBP myelin basic protein
METTL7A methyltransferase like 7A
MT1M metallothionein 1M
NPC1 Niemann-Pick disease, type C1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PNMA2 paraneoplastic Ma antigen 2
RABGAP1L RAB GTPase activating protein 1-like
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RPS4Y1 ribosomal protein S4, Y-linked 1
SKAP2 src kinase associated phosphoprotein 2
SLC35F2 solute carrier family 35, member F2
SOX4 SRY (sex determining region Y)-box 4
SYNGR3 synaptogyrin 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRABP2 cellular retinoic acid binding protein 2
EDRF1 erythroid differentiation regulatory factor 1
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IL17RB interleukin 17 receptor B
JMJD6 jumonji domain containing 6
LEF1 lymphoid enhancer-binding factor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
PI3 peptidase inhibitor 3, skin-derived
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
RAD51C RAD51 paralog C
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SRSF7 serine/arginine-rich splicing factor 7
ZDHHC6 zinc finger, DHHC-type containing 6
Funding