BRD-K12184916_NVP-BEZ235_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

207 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARHGAP32 Rho GTPase activating protein 32
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
COLEC12 collectin sub-family member 12
CRISP3 cysteine-rich secretory protein 3
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DIAPH2 diaphanous-related formin 2
EAPP E2F-associated phosphoprotein
EIF1B eukaryotic translation initiation factor 1B
EIF2D eukaryotic translation initiation factor 2D
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM63A family with sequence similarity 63, member A
FNBP1 formin binding protein 1
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD3 FXYD domain containing ion transport regulator 3
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GAS6 growth arrest-specific 6
GATAD1 GATA zinc finger domain containing 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPR137B G protein-coupled receptor 137B
GRN granulin
GSN gelsolin
GSTZ1 glutathione S-transferase zeta 1
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGBP1 immunoglobulin (CD79A) binding protein 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
KCTD12 potassium channel tetramerization domain containing 12
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KIAA0430 KIAA0430
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
LTA4H leukotriene A4 hydrolase
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2K5 mitogen-activated protein kinase kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MTMR11 myotubularin related protein 11
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLIP myosin regulatory light chain interacting protein
NBR1 neighbor of BRCA1 gene 1
NEK9 NIMA-related kinase 9
NPDC1 neural proliferation, differentiation and control, 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
NUPR1 nuclear protein, transcriptional regulator, 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM5 PDZ and LIM domain 5
PEG10 paternally expressed 10
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLK2 polo-like kinase 2
PNMAL1 paraneoplastic Ma antigen family-like 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RALGDS ral guanine nucleotide dissociation stimulator
RIOK3 RIO kinase 3
RPL15 ribosomal protein L15
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SEPP1 selenoprotein P, plasma, 1
SERINC1 serine incorporator 1
SGCE sarcoglycan, epsilon
SMAD3 SMAD family member 3
SOCS2 suppressor of cytokine signaling 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPATA20 spermatogenesis associated 20
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT5B signal transducer and activator of transcription 5B
STX16 syntaxin 16
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN31 tetraspanin 31
TXNIP thioredoxin interacting protein
UBXN1 UBX domain protein 1
WASL Wiskott-Aldrich syndrome-like
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZBTB38 zinc finger and BTB domain containing 38
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF217 zinc finger protein 217
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACOT7 acyl-CoA thioesterase 7
ACSL1 acyl-CoA synthetase long-chain family member 1
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BRCA1 breast cancer 1, early onset
C20ORF24 chromosome 20 open reading frame 24
CA2 carbonic anhydrase II
CALR calreticulin
CCNA2 cyclin A2
CCND3 cyclin D3
CCNE2 cyclin E2
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CTPS1 CTP synthase 1
DHCR7 7-dehydrocholesterol reductase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ENO1 enolase 1, (alpha)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IGKC immunoglobulin kappa constant
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ISG15 ISG15 ubiquitin-like modifier
KAZN kazrin, periplakin interacting protein
KIAA0101 KIAA0101
LMNB1 lamin B1
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDNF neuron-derived neurotrophic factor
NME1 NME/NM23 nucleoside diphosphate kinase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PGC progastricsin (pepsinogen C)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
RAD54B RAD54 homolog B (S. cerevisiae)
RANBP1 RAN binding protein 1
RBP4 retinol binding protein 4, plasma
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SDC2 syndecan 2
SDF2L1 stromal cell-derived factor 2-like 1
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLN sarcolipin
SMC1A structural maintenance of chromosomes 1A
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF4 transcription factor 4
TFDP1 transcription factor Dp-1
TMEM47 transmembrane protein 47
TUBA4A tubulin, alpha 4a
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
ZWINT ZW10 interacting kinetochore protein
Funding