BRD-K12184916_NVP-BEZ235_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ATG12 autophagy related 12
BACE2 beta-site APP-cleaving enzyme 2
BICD1 bicaudal D homolog 1 (Drosophila)
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP68 centrosomal protein 68kDa
CLEC2B C-type lectin domain family 2, member B
CREBL2 cAMP responsive element binding protein-like 2
CRISP3 cysteine-rich secretory protein 3
CST1 cystatin SN
CTSL cathepsin L
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM134B family with sequence similarity 134, member B
FOXO3 forkhead box O3
FZD6 frizzled class receptor 6
GAB2 GRB2-associated binding protein 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
KDM5A lysine (K)-specific demethylase 5A
KIAA1033 KIAA1033
KLHL24 kelch-like family member 24
LCN2 lipocalin 2
LRP12 low density lipoprotein receptor-related protein 12
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MANSC1 MANSC domain containing 1
MLPH melanophilin
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYLIP myosin regulatory light chain interacting protein
MYO6 myosin VI
NBPF10 neuroblastoma breakpoint family, member 10
NCK2 NCK adaptor protein 2
NDRG1 N-myc downstream regulated 1
NPAS2 neuronal PAS domain protein 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
OSER1 oxidative stress responsive serine-rich 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PDLIM5 PDZ and LIM domain 5
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
PNMA2 paraneoplastic Ma antigen 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PTPRF protein tyrosine phosphatase, receptor type, F
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RGS10 regulator of G-protein signaling 10
RGS20 regulator of G-protein signaling 20
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SECISBP2L SECIS binding protein 2-like
SFRP4 secreted frizzled-related protein 4
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SQSTM1 sequestosome 1
STXBP2 syntaxin binding protein 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBL1X transducin (beta)-like 1X-linked
TMEM63A transmembrane protein 63A
TPP1 tripeptidyl peptidase I
VEGFA vascular endothelial growth factor A
YBX3 Y box binding protein 3
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF217 zinc finger protein 217
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK1 adenylate kinase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
BIRC5 baculoviral IAP repeat containing 5
C4BPA complement component 4 binding protein, alpha
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCND3 cyclin D3
CD47 CD47 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CHRDL1 chordin-like 1
CLU clusterin
COL1A2 collagen, type I, alpha 2
CTPS1 CTP synthase 1
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DNASE1L3 deoxyribonuclease I-like 3
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FOLR1 folate receptor 1 (adult)
FRZB frizzled-related protein
HBB hemoglobin, beta
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA1A heat shock 70kDa protein 1A
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
IPO13 importin 13
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIMCH1 LIM and calponin homology domains 1
LMO4 LIM domain only 4
MAGEA3 melanoma antigen family A3
MARS methionyl-tRNA synthetase
MCAM melanoma cell adhesion molecule
MFAP4 microfibrillar-associated protein 4
MGP matrix Gla protein
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NES nestin
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
PARP2 poly (ADP-ribose) polymerase 2
PCCB propionyl CoA carboxylase, beta polypeptide
PLAC8 placenta-specific 8
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRDX2 peroxiredoxin 2
PRSS2 protease, serine, 2 (trypsin 2)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PYCR1 pyrroline-5-carboxylate reductase 1
QDPR quinoid dihydropteridine reductase
SDC2 syndecan 2
SFTPB surfactant protein B
SFTPD surfactant protein D
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLPI secretory leukocyte peptidase inhibitor
SMC1A structural maintenance of chromosomes 1A
SMC4 structural maintenance of chromosomes 4
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TRA2B transformer 2 beta homolog (Drosophila)
TUBG1 tubulin, gamma 1
Funding