BRD-K12184916_NVP-BEZ235_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K12184916_NVP-BEZ235_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPE centromere protein E, 312kDa
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP5 dual specificity phosphatase 5
EDN1 endothelin 1
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GFOD1 glucose-fructose oxidoreductase domain containing 1
GRB7 growth factor receptor-bound protein 7
HMGB2 high mobility group box 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KIAA0355 KIAA0355
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
MAN1A1 mannosidase, alpha, class 1A, member 1
MGLL monoglyceride lipase
MYOF myoferlin
MYRF myelin regulatory factor
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSRC1 proline/serine-rich coiled-coil 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC2 stanniocalcin 2
TFRC transferrin receptor
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UGCG UDP-glucose ceramide glucosyltransferase
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
C1ORF115 chromosome 1 open reading frame 115
CCND2 cyclin D2
CD14 CD14 molecule
CDC25A cell division cycle 25A
CHGB chromogranin B
CSRP1 cysteine and glycine-rich protein 1
CXCL5 chemokine (C-X-C motif) ligand 5
EREG epiregulin
FERMT1 fermitin family member 1
FOXC1 forkhead box C1
G0S2 G0/G1 switch 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HMG20B high mobility group 20B
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
MAP1B microtubule-associated protein 1B
MT1X metallothionein 1X
NEFH neurofilament, heavy polypeptide
PRKCZ protein kinase C, zeta
PUF60 poly-U binding splicing factor 60KDa
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFN stratifin
SIX2 SIX homeobox 2
SPEN spen family transcriptional repressor
SRRM2 serine/arginine repetitive matrix 2
TFF3 trefoil factor 3 (intestinal)
WBP5 WW domain binding protein 5
Funding