BRD-K12244279_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K12244279_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADD3 adducin 3 (gamma)
BRD8 bromodomain containing 8
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
JAK1 Janus kinase 1
KIF20A kinesin family member 20A
OLFM4 olfactomedin 4
PEG3 paternally expressed 3
PEX11A peroxisomal biogenesis factor 11 alpha
RNF167 ring finger protein 167
TCTA T-cell leukemia translocation altered

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BCAR3 breast cancer anti-estrogen resistance 3
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDCA4 cell division cycle associated 4
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN18 claudin 18
CST7 cystatin F (leukocystatin)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
FAM3C family with sequence similarity 3, member C
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSAP gamma-secretase activating protein
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HPCAL1 hippocalcin-like 1
IDO1 indoleamine 2,3-dioxygenase 1
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB5 integrin, beta 5
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALT1 MALT1 paracaspase
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLPH melanophilin
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MTCL1 microtubule crosslinking factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NNMT nicotinamide N-methyltransferase
NOP2 NOP2 nucleolar protein
NPAS2 neuronal PAS domain protein 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUAK1 NUAK family, SNF1-like kinase, 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEK2 pleckstrin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PTPN12 protein tyrosine phosphatase, non-receptor type 12
S100A2 S100 calcium binding protein A2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH2B3 SH2B adaptor protein 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SST somatostatin
STX1A syntaxin 1A (brain)
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSC22D1 TSC22 domain family, member 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFC vascular endothelial growth factor C