| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
| Downloads & Tools |
343 genes differentially expressed following the BRD-K12343256_trametinib_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABHD4 | abhydrolase domain containing 4 |
| ABLIM1 | actin binding LIM protein 1 |
| ACSF2 | acyl-CoA synthetase family member 2 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
| ADGRG1 | adhesion G protein-coupled receptor G1 |
| ADIRF | adipogenesis regulatory factor |
| AHNAK | AHNAK nucleoprotein |
| AHNAK2 | AHNAK nucleoprotein 2 |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| AKR1C3 | aldo-keto reductase family 1, member C3 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 |
| ANXA4 | annexin A4 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 |
| ASS1 | argininosuccinate synthase 1 |
| ATF3 | activating transcription factor 3 |
| AVPI1 | arginine vasopressin-induced 1 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
| C10ORF10 | chromosome 10 open reading frame 10 |
| CALCOCO1 | calcium binding and coiled-coil domain 1 |
| CAT | catalase |
| CCNG2 | cyclin G2 |
| CD99 | CD99 molecule |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| CFB | complement factor B |
| CFD | complement factor D (adipsin) |
| CLEC3B | C-type lectin domain family 3, member B |
| COL1A1 | collagen, type I, alpha 1 |
| COL4A1 | collagen, type IV, alpha 1 |
| COL9A3 | collagen, type IX, alpha 3 |
| CRYAB | crystallin, alpha B |
| CTSA | cathepsin A |
| CTTN | cortactin |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 |
| DCN | decorin |
| DLG5 | discs, large homolog 5 (Drosophila) |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 |
| DSP | desmoplakin |
| DUSP1 | dual specificity phosphatase 1 |
| DUSP14 | dual specificity phosphatase 14 |
| ECM2 | extracellular matrix protein 2, female organ and adipocyte specific |
| EFNA1 | ephrin-A1 |
| EPAS1 | endothelial PAS domain protein 1 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 |
| EPS8L2 | EPS8-like 2 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 |
| FAM134B | family with sequence similarity 134, member B |
| FAM63A | family with sequence similarity 63, member A |
| FBN1 | fibrillin 1 |
| FILIP1L | filamin A interacting protein 1-like |
| FLNB | filamin B, beta |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 |
| FOLR1 | folate receptor 1 (adult) |
| FOSL2 | FOS-like antigen 2 |
| FOXO4 | forkhead box O4 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) |
| GADD45B | growth arrest and DNA-damage-inducible, beta |
| GATA3 | GATA binding protein 3 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 |
| GJA1 | gap junction protein, alpha 1, 43kDa |
| GLS | glutaminase |
| GLUL | glutamate-ammonia ligase |
| GPX4 | glutathione peroxidase 4 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit |
| HBP1 | HMG-box transcription factor 1 |
| HGSNAT | heparan-alpha-glucosaminide N-acetyltransferase |
| HLA-F | major histocompatibility complex, class I, F |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase |
| HMOX1 | heme oxygenase 1 |
| HOXA5 | homeobox A5 |
| HSPB8 | heat shock 22kDa protein 8 |
| IFI27 | interferon, alpha-inducible protein 27 |
| IGFBP3 | insulin-like growth factor binding protein 3 |
| IGFBP6 | insulin-like growth factor binding protein 6 |
| IGFBP7 | insulin-like growth factor binding protein 7 |
| IGKC | immunoglobulin kappa constant |
| IL32 | interleukin 32 |
| JUN | jun proto-oncogene |
| JUND | jun D proto-oncogene |
| JUP | junction plakoglobin |
| KIAA1598 | |
| KLF6 | Kruppel-like factor 6 |
| KRT14 | keratin 14, type I |
| KRT17 | keratin 17, type I |
| KRT5 | keratin 5, type II |
| LAMA3 | laminin, alpha 3 |
| LOX | lysyl oxidase |
| LTBP2 | latent transforming growth factor beta binding protein 2 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog |
| MAOA | monoamine oxidase A |
| MAP7 | microtubule-associated protein 7 |
| MATN2 | matrilin 2 |
| MCAM | melanoma cell adhesion molecule |
| MEOX2 | mesenchyme homeobox 2 |
| MFAP5 | microfibrillar associated protein 5 |
| MSMO1 | methylsterol monooxygenase 1 |
| MTMR11 | myotubularin related protein 11 |
| MVP | major vault protein |
| MXI1 | MAX interactor 1, dimerization protein |
| NDRG1 | N-myc downstream regulated 1 |
| NFIL3 | nuclear factor, interleukin 3 regulated |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
| NREP | neuronal regeneration related protein |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| OBSL1 | obscurin-like 1 |
| OPTN | optineurin |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
| PDGFD | platelet derived growth factor D |
| PDZK1IP1 | PDZK1 interacting protein 1 |
| PECAM1 | platelet/endothelial cell adhesion molecule 1 |
| PHYH | phytanoyl-CoA 2-hydroxylase |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 |
| PLCB4 | phospholipase C, beta 4 |
| POSTN | periostin, osteoblast specific factor |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 |
| PXDN | peroxidasin |
| PYCARD | PYD and CARD domain containing |
| RAB32 | RAB32, member RAS oncogene family |
| RAB9A | RAB9A, member RAS oncogene family |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 |
| RHOB | ras homolog family member B |
| SCARB1 | scavenger receptor class B, member 1 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| SFN | stratifin |
| SFXN3 | sideroflexin 3 |
| SGK1 | serum/glucocorticoid regulated kinase 1 |
| SIK1 | salt-inducible kinase 1 |
| SKAP2 | src kinase associated phosphoprotein 2 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 |
| SNAI2 | snail family zinc finger 2 |
| SOX4 | SRY (sex determining region Y)-box 4 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) |
| SPON2 | spondin 2, extracellular matrix protein |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) |
| STOM | stomatin |
| STXBP2 | syntaxin binding protein 2 |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
| SULT1A2 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 |
| SYNGR3 | synaptogyrin 3 |
| SYNPO | synaptopodin |
| TAGLN2 | transgelin 2 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) |
| TPM2 | tropomyosin 2 (beta) |
| TRIM29 | tripartite motif containing 29 |
| TSC22D3 | TSC22 domain family, member 3 |
| TSKU | tsukushi, small leucine rich proteoglycan |
| TUFT1 | tuftelin 1 |
| TXNIP | thioredoxin interacting protein |
| UGDH | UDP-glucose 6-dehydrogenase |
| VAT1 | vesicle amine transport 1 |
| VCL | vinculin |
| VGLL4 | vestigial-like family member 4 |
| WISP2 | WNT1 inducible signaling pathway protein 2 |
| YPEL5 | yippee-like 5 (Drosophila) |
| ZFP36 | ZFP36 ring finger protein |
| Symbol | Name |
|---|---|
| ADCK3 | aarF domain containing kinase 3 |
| AGR2 | anterior gradient 2 |
| ANXA3 | annexin A3 |
| ARL4C | ADP-ribosylation factor-like 4C |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) |
| ASRGL1 | asparaginase like 1 |
| ATAD2 | ATPase family, AAA domain containing 2 |
| AURKA | aurora kinase A |
| BIRC5 | baculoviral IAP repeat containing 5 |
| BLM | Bloom syndrome, RecQ helicase-like |
| C7 | complement component 7 |
| CCNA2 | cyclin A2 |
| CCND1 | cyclin D1 |
| CDC25A | cell division cycle 25A |
| CDC6 | cell division cycle 6 |
| CDCA4 | cell division cycle associated 4 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) |
| CDK1 | cyclin-dependent kinase 1 |
| CDT1 | chromatin licensing and DNA replication factor 1 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) |
| CENPA | centromere protein A |
| CENPE | centromere protein E, 312kDa |
| CHEK1 | checkpoint kinase 1 |
| CHEK2 | checkpoint kinase 2 |
| CIT | citron rho-interacting serine/threonine kinase |
| CKLF | chemokine-like factor |
| CRISP3 | cysteine-rich secretory protein 3 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| DBF4 | DBF4 zinc finger |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 |
| DEFA4 | defensin, alpha 4, corticostatin |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
| DSCC1 | DNA replication and sister chromatid cohesion 1 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP6 | dual specificity phosphatase 6 |
| E2F8 | E2F transcription factor 8 |
| ECT2 | epithelial cell transforming 2 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) |
| EPHA2 | EPH receptor A2 |
| ETV1 | ets variant 1 |
| ETV4 | ets variant 4 |
| ETV5 | ets variant 5 |
| EXO1 | exonuclease 1 |
| FANCI | Fanconi anemia, complementation group I |
| FBXO5 | F-box protein 5 |
| FEN1 | flap structure-specific endonuclease 1 |
| FKBP14 | FK506 binding protein 14, 22 kDa |
| FOSL1 | FOS-like antigen 1 |
| GABRA2 | gamma-aminobutyric acid (GABA) A receptor, alpha 2 |
| GCA | grancalcin, EF-hand calcium binding protein |
| GDF15 | growth differentiation factor 15 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GINS3 | GINS complex subunit 3 (Psf3 homolog) |
| GSAP | gamma-secretase activating protein |
| GTSE1 | G-2 and S-phase expressed 1 |
| HAT1 | histone acetyltransferase 1 |
| HJURP | Holliday junction recognition protein |
| HMGA1 | high mobility group AT-hook 1 |
| HMGA2 | high mobility group AT-hook 2 |
| HP | haptoglobin |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
| IER3 | immediate early response 3 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa |
| IGFBP4 | insulin-like growth factor binding protein 4 |
| IGFBP5 | insulin-like growth factor binding protein 5 |
| IL13RA2 | interleukin 13 receptor, alpha 2 |
| IL1R2 | interleukin 1 receptor, type II |
| ITGB5 | integrin, beta 5 |
| KIF14 | kinesin family member 14 |
| KIF18B | kinesin family member 18B |
| KIF20A | kinesin family member 20A |
| LAMP5 | lysosomal-associated membrane protein family, member 5 |
| LHX2 | LIM homeobox 2 |
| LIG1 | ligase I, DNA, ATP-dependent |
| LMNB1 | lamin B1 |
| LMNB2 | lamin B2 |
| LTF | lactotransferrin |
| LYZ | lysozyme |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| MCM10 | minichromosome maintenance complex component 10 |
| MCM3 | minichromosome maintenance complex component 3 |
| MCM4 | minichromosome maintenance complex component 4 |
| MCM5 | minichromosome maintenance complex component 5 |
| MIS18A | MIS18 kinetochore protein A |
| MLPH | melanophilin |
| MMP9 | matrix metallopeptidase 9 |
| MSH2 | mutS homolog 2 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| NAV3 | neuron navigator 3 |
| NCAPG | non-SMC condensin I complex, subunit G |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) |
| NOP2 | NOP2 nucleolar protein |
| NPY | neuropeptide Y |
| NRGN | neurogranin (protein kinase C substrate, RC3) |
| NT5E | 5'-nucleotidase, ecto (CD73) |
| NTS | neurotensin |
| ORC6 | origin recognition complex, subunit 6 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 |
| PDE4B | phosphodiesterase 4B, cAMP-specific |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 |
| PHGDH | phosphoglycerate dehydrogenase |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
| PIH1D1 | PIH1 domain containing 1 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha |
| PLK1 | polo-like kinase 1 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
| POLR3K | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa |
| PPAT | phosphoribosyl pyrophosphate amidotransferase |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) |
| PRKCH | protein kinase C, eta |
| PSAT1 | phosphoserine aminotransferase 1 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 |
| RAD51AP1 | RAD51 associated protein 1 |
| RAP1GAP | RAP1 GTPase activating protein |
| RFC2 | replication factor C (activator 1) 2, 40kDa |
| RFC3 | replication factor C (activator 1) 3, 38kDa |
| RFC4 | replication factor C (activator 1) 4, 37kDa |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa |
| RGS2 | regulator of G-protein signaling 2 |
| RGS4 | regulator of G-protein signaling 4 |
| RPIA | ribose 5-phosphate isomerase A |
| RRM2 | ribonucleotide reductase M2 |
| RRP15 | ribosomal RNA processing 15 homolog (S. cerevisiae) |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 |
| SFRP1 | secreted frizzled-related protein 1 |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 |
| SLC35F2 | solute carrier family 35, member F2 |
| SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 |
| SMC4 | structural maintenance of chromosomes 4 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing |
| SOX9 | SRY (sex determining region Y)-box 9 |
| SPARCL1 | SPARC-like 1 (hevin) |
| SPC25 | SPC25, NDC80 kinetochore complex component |
| SPON1 | spondin 1, extracellular matrix protein |
| SPRED2 | sprouty-related, EVH1 domain containing 2 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) |
| SPRY2 | sprouty homolog 2 (Drosophila) |
| SPRY4 | sprouty homolog 4 (Drosophila) |
| SQRDL | sulfide quinone reductase-like (yeast) |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 |
| STX1A | syntaxin 1A (brain) |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| SYT1 | synaptotagmin I |
| TACC3 | transforming, acidic coiled-coil containing protein 3 |
| TFF3 | trefoil factor 3 (intestinal) |
| TFPI2 | tissue factor pathway inhibitor 2 |
| TIPIN | TIMELESS interacting protein |
| TK1 | thymidine kinase 1, soluble |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) |
| TMEM97 | transmembrane protein 97 |
| TMPO | thymopoietin |
| TRIB2 | tribbles pseudokinase 2 |
| TRIB3 | tribbles pseudokinase 3 |
| TSPAN13 | tetraspanin 13 |
| TSPAN5 | tetraspanin 5 |
| TSPAN8 | tetraspanin 8 |
| TYMS | thymidylate synthetase |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| USP1 | ubiquitin specific peptidase 1 |
| WDHD1 | WD repeat and HMG-box DNA binding protein 1 |
| WDR3 | WD repeat domain 3 |
| WHSC1 | Wolf-Hirschhorn syndrome candidate 1 |
| WNT5A | wingless-type MMTV integration site family, member 5A |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing |
