BRD-K12343256_trametinib_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K12343256_trametinib_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADGRG2 adhesion G protein-coupled receptor G2
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
BCL6 B-cell CLL/lymphoma 6
BST2 bone marrow stromal cell antigen 2
CA11 carbonic anhydrase XI
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
COL4A5 collagen, type IV, alpha 5
CSTA cystatin A (stefin A)
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FGG fibrinogen gamma chain
FXYD3 FXYD domain containing ion transport regulator 3
GLUL glutamate-ammonia ligase
GSN gelsolin
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JCHAIN joining chain of multimeric IgA and IgM
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LCN2 lipocalin 2
MAOA monoamine oxidase A
MUC4 mucin 4, cell surface associated
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NPTX2 neuronal pentraxin II
PDZK1IP1 PDZK1 interacting protein 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRUNE2 prune homolog 2 (Drosophila)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SELENBP1 selenium binding protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VWA1 von Willebrand factor A domain containing 1
WIF1 WNT inhibitory factor 1
YPEL5 yippee-like 5 (Drosophila)
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ANXA3 annexin A3
AREG amphiregulin
CALML5 calmodulin-like 5
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CDC25A cell division cycle 25A
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYR61 cysteine-rich, angiogenic inducer, 61
DLX2 distal-less homeobox 2
DUSP4 dual specificity phosphatase 4
E2F2 E2F transcription factor 2
ETV1 ets variant 1
FABP7 fatty acid binding protein 7, brain
FOSL1 FOS-like antigen 1
GPX3 glutathione peroxidase 3
HMGA1 high mobility group AT-hook 1
IER3 immediate early response 3
ITGB5 integrin, beta 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM7 minichromosome maintenance complex component 7
NFIB nuclear factor I/B
NT5E 5'-nucleotidase, ecto (CD73)
RPL37A ribosomal protein L37a
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SLC43A3 solute carrier family 43, member 3
TNC tenascin C
TOR1A torsin family 1, member A (torsin A)
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