BRD-K12343256_trametinib_BT20_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

39 genes differentially expressed following the BRD-K12343256_trametinib_BT20_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
CKAP4 cytoskeleton-associated protein 4
HOXC6 homeobox C6
IGFBP7 insulin-like growth factor binding protein 7
LAMC1 laminin, gamma 1 (formerly LAMB2)
LIMCH1 LIM and calponin homology domains 1
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP9 aquaporin 9
ATF3 activating transcription factor 3
BID BH3 interacting domain death agonist
CCND1 cyclin D1
CHN1 chimerin 1
COL11A1 collagen, type XI, alpha 1
COL6A2 collagen, type VI, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EGR3 early growth response 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GEM GTP binding protein overexpressed in skeletal muscle
GSTT1 glutathione S-transferase theta 1
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
KLK10 kallikrein-related peptidase 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MYC v-myc avian myelocytomatosis viral oncogene homolog
PI3 peptidase inhibitor 3, skin-derived
PLAUR plasminogen activator, urokinase receptor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RND3 Rho family GTPase 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORD sorbitol dehydrogenase
TMEM176B transmembrane protein 176B
TRD T cell receptor delta locus
Funding