BRD-K12343256_trametinib_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K12343256_trametinib_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
ASS1 argininosuccinate synthase 1
CLEC2B C-type lectin domain family 2, member B
CP ceruloplasmin (ferroxidase)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
FNBP1 formin binding protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IL1R1 interleukin 1 receptor, type I
INSR insulin receptor
KRT7 keratin 7, type II
LAMP3 lysosomal-associated membrane protein 3
LYN LYN proto-oncogene, Src family tyrosine kinase
MEIS1 Meis homeobox 1
NLRP2 NLR family, pyrin domain containing 2
PEX11A peroxisomal biogenesis factor 11 alpha
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SLPI secretory leukocyte peptidase inhibitor
SPARCL1 SPARC-like 1 (hevin)
STOM stomatin

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AREG amphiregulin
ASPH aspartate beta-hydroxylase
BEX1 brain expressed, X-linked 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP14 dual specificity phosphatase 14
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
FABP4 fatty acid binding protein 4, adipocyte
FAM198B family with sequence similarity 198, member B
FOSL1 FOS-like antigen 1
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GLIPR1 GLI pathogenesis-related 1
HAS2 hyaluronan synthase 2
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
JMJD6 jumonji domain containing 6
KLF10 Kruppel-like factor 10
LDHB lactate dehydrogenase B
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS4 lectin, galactoside-binding, soluble, 4
LTF lactotransferrin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PTX3 pentraxin 3, long
RGS4 regulator of G-protein signaling 4
S100A12 S100 calcium binding protein A12
SAMHD1 SAM domain and HD domain 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
SRSF2 serine/arginine-rich splicing factor 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TNC tenascin C
VEGFC vascular endothelial growth factor C
ZEB2 zinc finger E-box binding homeobox 2
Funding