| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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339 genes differentially expressed following the BRD-K12343256_trametinib_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| AAMDC | adipogenesis associated, Mth938 domain containing |
| ABAT | 4-aminobutyrate aminotransferase |
| ACKR3 | atypical chemokine receptor 3 |
| ADD3 | adducin 3 (gamma) |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| AKR1C3 | aldo-keto reductase family 1, member C3 |
| AMACR | alpha-methylacyl-CoA racemase |
| ANKRD36B | ankyrin repeat domain 36B |
| ANXA4 | annexin A4 |
| ARMCX1 | armadillo repeat containing, X-linked 1 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 |
| ATP9A | ATPase, class II, type 9A |
| BAMBI | BMP and activin membrane-bound inhibitor |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B |
| BBS1 | Bardet-Biedl syndrome 1 |
| BLNK | B-cell linker |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
| BTG1 | B-cell translocation gene 1, anti-proliferative |
| C10ORF10 | chromosome 10 open reading frame 10 |
| C1ORF106 | chromosome 1 open reading frame 106 |
| C1RL | complement component 1, r subcomponent-like |
| CALCOCO1 | calcium binding and coiled-coil domain 1 |
| CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
| CCNG2 | cyclin G2 |
| CCPG1 | cell cycle progression 1 |
| CD24 | CD24 molecule |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha |
| CEP70 | centrosomal protein 70kDa |
| CES2 | carboxylesterase 2 |
| CFB | complement factor B |
| CFI | complement factor I |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
| CLIC5 | chloride intracellular channel 5 |
| CRYAB | crystallin, alpha B |
| CTSA | cathepsin A |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 |
| DDAH2 | dimethylarginine dimethylaminohydrolase 2 |
| DDIT4 | DNA-damage-inducible transcript 4 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial |
| DEFB1 | defensin, beta 1 |
| DIAPH2 | diaphanous-related formin 2 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
| EFHC1 | EF-hand domain (C-terminal) containing 1 |
| EFNA1 | ephrin-A1 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 |
| FAM107A | family with sequence similarity 107, member A |
| FGFR2 | fibroblast growth factor receptor 2 |
| FOLR1 | folate receptor 1 (adult) |
| FOXO3 | forkhead box O3 |
| FOXO4 | forkhead box O4 |
| GPX3 | glutathione peroxidase 3 |
| GSDMB | gasdermin B |
| GSN | gelsolin |
| HBP1 | HMG-box transcription factor 1 |
| HECA | headcase homolog (Drosophila) |
| HIST1H1C | histone cluster 1, H1c |
| HIST1H2AC | histone cluster 1, H2ac |
| HIST1H2BD | histone cluster 1, H2bd |
| HIST3H2A | histone cluster 3, H2a |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 |
| HLA-E | major histocompatibility complex, class I, E |
| HMGCL | 3-hydroxymethyl-3-methylglutaryl-CoA lyase |
| HMOX1 | heme oxygenase 1 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble |
| IL1R1 | interleukin 1 receptor, type I |
| INSIG2 | insulin induced gene 2 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 |
| KDM3A | lysine (K)-specific demethylase 3A |
| KLF5 | Kruppel-like factor 5 (intestinal) |
| KLHL24 | kelch-like family member 24 |
| KRT7 | keratin 7, type II |
| LAMA3 | laminin, alpha 3 |
| LCN2 | lipocalin 2 |
| LXN | latexin |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B |
| MAOA | monoamine oxidase A |
| MID1 | midline 1 |
| MVP | major vault protein |
| MXI1 | MAX interactor 1, dimerization protein |
| N4BP2L2 | NEDD4 binding protein 2-like 2 |
| NBR1 | neighbor of BRCA1 gene 1 |
| NCK2 | NCK adaptor protein 2 |
| NMRK1 | nicotinamide riboside kinase 1 |
| NOV | nephroblastoma overexpressed |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| OFD1 | oral-facial-digital syndrome 1 |
| OLFM4 | olfactomedin 4 |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 |
| PBLD | phenazine biosynthesis-like protein domain containing |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
| PDZK1 | PDZ domain containing 1 |
| PDZK1IP1 | PDZK1 interacting protein 1 |
| PHYH | phytanoyl-CoA 2-hydroxylase |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) |
| PINK1 | PTEN induced putative kinase 1 |
| PPL | periplakin |
| PROM1 | prominin 1 |
| PROS1 | protein S (alpha) |
| PRR15L | proline rich 15-like |
| PRSS8 | protease, serine, 8 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 |
| QPRT | quinolinate phosphoribosyltransferase |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) |
| RAB29 | RAB29, member RAS oncogene family |
| RAB9A | RAB9A, member RAS oncogene family |
| RABGAP1L | RAB GTPase activating protein 1-like |
| RALGPS1 | Ral GEF with PH domain and SH3 binding motif 1 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 |
| RB1CC1 | RB1-inducible coiled-coil 1 |
| RBKS | ribokinase |
| RBP4 | retinol binding protein 4, plasma |
| REG1A | regenerating islet-derived 1 alpha |
| SCGB2A1 | secretoglobin, family 2A, member 1 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) |
| SELENBP1 | selenium binding protein 1 |
| SEPP1 | selenoprotein P, plasma, 1 |
| SESN1 | sestrin 1 |
| SKAP2 | src kinase associated phosphoprotein 2 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| SLC35E2B | solute carrier family 35, member E2B |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 |
| SLC44A4 | solute carrier family 44, member 4 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
| SLPI | secretory leukocyte peptidase inhibitor |
| SOX4 | SRY (sex determining region Y)-box 4 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 |
| TMEM30B | transmembrane protein 30B |
| TMEM59 | transmembrane protein 59 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 |
| TNS3 | tensin 3 |
| TOX | thymocyte selection-associated high mobility group box |
| TPP1 | tripeptidyl peptidase I |
| TRIM2 | tripartite motif containing 2 |
| TSC22D3 | TSC22 domain family, member 3 |
| TSPAN1 | tetraspanin 1 |
| TSPAN31 | tetraspanin 31 |
| TTC39A | tetratricopeptide repeat domain 39A |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) |
| VWA5A | von Willebrand factor A domain containing 5A |
| WDR19 | WD repeat domain 19 |
| WFDC2 | WAP four-disulfide core domain 2 |
| YPEL5 | yippee-like 5 (Drosophila) |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 |
| ZSWIM8 | zinc finger, SWIM-type containing 8 |
| Symbol | Name |
|---|---|
| ABCE1 | ATP-binding cassette, sub-family E (OABP), member 1 |
| ADORA2B | adenosine A2b receptor |
| AMD1 | adenosylmethionine decarboxylase 1 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha |
| ASF1B | anti-silencing function 1B histone chaperone |
| ATAD2 | ATPase family, AAA domain containing 2 |
| ATF5 | activating transcription factor 5 |
| AURKA | aurora kinase A |
| AURKB | aurora kinase B |
| BIRC5 | baculoviral IAP repeat containing 5 |
| BOP1 | block of proliferation 1 |
| BYSL | bystin-like |
| C1QBP | complement component 1, q subcomponent binding protein |
| CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
| CCNA2 | cyclin A2 |
| CCND1 | cyclin D1 |
| CCNE2 | cyclin E2 |
| CD320 | CD320 molecule |
| CD3EAP | CD3e molecule, epsilon associated protein |
| CDC20 | cell division cycle 20 |
| CDC25A | cell division cycle 25A |
| CDC45 | cell division cycle 45 |
| CDC6 | cell division cycle 6 |
| CDCA3 | cell division cycle associated 3 |
| CDK1 | cyclin-dependent kinase 1 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 |
| CDT1 | chromatin licensing and DNA replication factor 1 |
| CENPN | centromere protein N |
| CENPU | centromere protein U |
| CEP55 | centrosomal protein 55kDa |
| CHEK1 | checkpoint kinase 1 |
| CHEK2 | checkpoint kinase 2 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 |
| CIT | citron rho-interacting serine/threonine kinase |
| CKS2 | CDC28 protein kinase regulatory subunit 2 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 |
| CTPS1 | CTP synthase 1 |
| CYR61 | cysteine-rich, angiogenic inducer, 61 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 |
| DKC1 | dyskeratosis congenita 1, dyskerin |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 |
| DPH2 | DPH2 homolog (S. cerevisiae) |
| DSCC1 | DNA replication and sister chromatid cohesion 1 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DUSP6 | dual specificity phosphatase 6 |
| ECT2 | epithelial cell transforming 2 |
| EEF1E1 | eukaryotic translation elongation factor 1 epsilon 1 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked |
| EIF3B | eukaryotic translation initiation factor 3, subunit B |
| ELOVL6 | ELOVL fatty acid elongase 6 |
| EMG1 | EMG1 N1-specific pseudouridine methyltransferase |
| ENO1 | enolase 1, (alpha) |
| EREG | epiregulin |
| EXO1 | exonuclease 1 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FAM216A | family with sequence similarity 216, member A |
| FASN | fatty acid synthase |
| FAT1 | FAT atypical cadherin 1 |
| FEN1 | flap structure-specific endonuclease 1 |
| FOSL1 | FOS-like antigen 1 |
| FOXM1 | forkhead box M1 |
| FST | follistatin |
| FXYD5 | FXYD domain containing ion transport regulator 5 |
| GAL | galanin/GMAP prepropeptide |
| GCH1 | GTP cyclohydrolase 1 |
| GEMIN4 | gem (nuclear organelle) associated protein 4 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GINS3 | GINS complex subunit 3 (Psf3 homolog) |
| GTPBP4 | GTP binding protein 4 |
| H2AFX | H2A histone family, member X |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 |
| HSPA8 | heat shock 70kDa protein 8 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) |
| IARS | isoleucyl-tRNA synthetase |
| IER3 | immediate early response 3 |
| IFRD2 | interferon-related developmental regulator 2 |
| INPP1 | inositol polyphosphate-1-phosphatase |
| ITGB5 | integrin, beta 5 |
| KCTD12 | potassium channel tetramerization domain containing 12 |
| KIAA0020 | KIAA0020 |
| KIAA0101 | KIAA0101 |
| LIG1 | ligase I, DNA, ATP-dependent |
| LMNB2 | lamin B2 |
| LOXL1 | lysyl oxidase-like 1 |
| LTF | lactotransferrin |
| LY6E | lymphocyte antigen 6 complex, locus E |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| MCM10 | minichromosome maintenance complex component 10 |
| MCM2 | minichromosome maintenance complex component 2 |
| MCM3 | minichromosome maintenance complex component 3 |
| MCM4 | minichromosome maintenance complex component 4 |
| MCM5 | minichromosome maintenance complex component 5 |
| MCM6 | minichromosome maintenance complex component 6 |
| MCM7 | minichromosome maintenance complex component 7 |
| MINA | MYC induced nuclear antigen |
| MKI67 | marker of proliferation Ki-67 |
| MRPL12 | mitochondrial ribosomal protein L12 |
| MRPL3 | mitochondrial ribosomal protein L3 |
| MRTO4 | mRNA turnover 4 homolog (S. cerevisiae) |
| MTCL1 | microtubule crosslinking factor 1 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog |
| NCAPD3 | non-SMC condensin II complex, subunit D3 |
| NCAPG | non-SMC condensin I complex, subunit G |
| NHP2 | NHP2 ribonucleoprotein |
| NLE1 | notchless homolog 1 (Drosophila) |
| NME1 | NME/NM23 nucleoside diphosphate kinase 1 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 |
| NOP16 | NOP16 nucleolar protein |
| NOP2 | NOP2 nucleolar protein |
| NOP56 | NOP56 ribonucleoprotein |
| NPM3 | nucleophosmin/nucleoplasmin 3 |
| NRGN | neurogranin (protein kinase C substrate, RC3) |
| NXT1 | nuclear transport factor 2-like export factor 1 |
| ODC1 | ornithine decarboxylase 1 |
| PA2G4 | proliferation-associated 2G4, 38kDa |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase |
| PBK | PDZ binding kinase |
| PCNA | proliferating cell nuclear antigen |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 |
| PFAS | phosphoribosylformylglycinamidine synthase |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
| PLK1 | polo-like kinase 1 |
| PNP | purine nucleoside phosphorylase |
| POLD2 | polymerase (DNA directed), delta 2, accessory subunit |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
| PPAT | phosphoribosyl pyrophosphate amidotransferase |
| PPIF | peptidylprolyl isomerase F |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 |
| PRC1 | protein regulator of cytokinesis 1 |
| PRMT1 | protein arginine methyltransferase 1 |
| PRMT5 | protein arginine methyltransferase 5 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| PUS7 | pseudouridylate synthase 7 (putative) |
| PYCR1 | pyrroline-5-carboxylate reductase 1 |
| RAD51 | RAD51 recombinase |
| RAN | RAN, member RAS oncogene family |
| RANBP1 | RAN binding protein 1 |
| RFC2 | replication factor C (activator 1) 2, 40kDa |
| RFC3 | replication factor C (activator 1) 3, 38kDa |
| RRM1 | ribonucleotide reductase M1 |
| RRM2 | ribonucleotide reductase M2 |
| RRP15 | ribosomal RNA processing 15 homolog (S. cerevisiae) |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) |
| SEH1L | SEH1-like (S. cerevisiae) |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 |
| SRM | spermidine synthase |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein |
| TACC3 | transforming, acidic coiled-coil containing protein 3 |
| TESC | tescalcin |
| THBS1 | thrombospondin 1 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) |
| TIPIN | TIMELESS interacting protein |
| TK1 | thymidine kinase 1, soluble |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) |
| TMPO | thymopoietin |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa |
| TPX2 | TPX2, microtubule-associated |
| TRIP13 | thyroid hormone receptor interactor 13 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) |
| TYMS | thymidylate synthetase |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| UCK2 | uridine-cytidine kinase 2 |
| VRK1 | vaccinia related kinase 1 |
| WDR12 | WD repeat domain 12 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 |
| ZWINT | ZW10 interacting kinetochore protein |
