BRD-K12343256_trametinib_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K12343256_trametinib_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANO10 anoctamin 10
BEX4 brain expressed, X-linked 4
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CLIC3 chloride intracellular channel 3
CPA3 carboxypeptidase A3 (mast cell)
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK1 death-associated protein kinase 1
DCN decorin
DUSP1 dual specificity phosphatase 1
DUSP22 dual specificity phosphatase 22
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM134B family with sequence similarity 134, member B
FGFR3 fibroblast growth factor receptor 3
FOCAD focadhesin
GAS1 growth arrest-specific 1
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMG20B high mobility group 20B
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL11RA interleukin 11 receptor, alpha
LUM lumican
MATN2 matrilin 2
MTSS1 metastasis suppressor 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NUPR1 nuclear protein, transcriptional regulator, 1
OSR2 odd-skipped related transciption factor 2
PDZD2 PDZ domain containing 2
PHACTR2 phosphatase and actin regulator 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLIN2 perilipin 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS2 regulator of G-protein signaling 2
SEPP1 selenoprotein P, plasma, 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
VAV3 vav 3 guanine nucleotide exchange factor
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADORA2B adenosine A2b receptor
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA10 annexin A10
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
CCND1 cyclin D1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
CST1 cystatin SN
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HP haptoglobin
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD14 potassium channel tetramerization domain containing 14
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPHN1 oligophrenin 1
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTN pleiotrophin
RGS4 regulator of G-protein signaling 4
RPIA ribose 5-phosphate isomerase A
RPS4Y1 ribosomal protein S4, Y-linked 1
SATB1 SATB homeobox 1
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SFTPB surfactant protein B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC43A3 solute carrier family 43, member 3
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
VEGFA vascular endothelial growth factor A
Funding