| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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132 genes differentially expressed following the BRD-K12343256_trametinib_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ARID5B | AT rich interactive domain 5B (MRF1-like) |
| ATHL1 | ATH1, acid trehalase-like 1 (yeast) |
| BAMBI | BMP and activin membrane-bound inhibitor |
| BCAM | basal cell adhesion molecule (Lutheran blood group) |
| BLVRB | biliverdin reductase B |
| CAPN1 | calpain 1, (mu/I) large subunit |
| CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta |
| CFB | complement factor B |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) |
| DHCR24 | 24-dehydrocholesterol reductase |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 |
| EFNA1 | ephrin-A1 |
| FADS3 | fatty acid desaturase 3 |
| FBLN1 | fibulin 1 |
| FILIP1L | filamin A interacting protein 1-like |
| FOLR1 | folate receptor 1 (adult) |
| FTH1 | ferritin, heavy polypeptide 1 |
| GLUL | glutamate-ammonia ligase |
| GPC1 | glypican 1 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B |
| HBP1 | HMG-box transcription factor 1 |
| HEG1 | heart development protein with EGF-like domains 1 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
| HSPB8 | heat shock 22kDa protein 8 |
| IGFBP3 | insulin-like growth factor binding protein 3 |
| IGHM | immunoglobulin heavy constant mu |
| IL1R1 | interleukin 1 receptor, type I |
| KRT18 | keratin 18, type I |
| LCN2 | lipocalin 2 |
| LOX | lysyl oxidase |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) |
| METTL7A | methyltransferase like 7A |
| MSLN | mesothelin |
| MSMO1 | methylsterol monooxygenase 1 |
| MUC1 | mucin 1, cell surface associated |
| NEU1 | sialidase 1 (lysosomal sialidase) |
| NIPSNAP1 | nipsnap homolog 1 (C. elegans) |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| NXN | nucleoredoxin |
| OBSL1 | obscurin-like 1 |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 |
| OSBPL9 | oxysterol binding protein-like 9 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
| PDLIM1 | PDZ and LIM domain 1 |
| PLBD1 | phospholipase B domain containing 1 |
| PRKCI | protein kinase C, iota |
| PSG5 | pregnancy specific beta-1-glycoprotein 5 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase |
| QPRT | quinolinate phosphoribosyltransferase |
| RHOB | ras homolog family member B |
| SC5D | sterol-C5-desaturase |
| SCGB1D2 | secretoglobin, family 1D, member 2 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
| SLPI | secretory leukocyte peptidase inhibitor |
| SQLE | squalene epoxidase |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
| STON1 | stonin 1 |
| TAGLN | transgelin |
| TMEM135 | transmembrane protein 135 |
| TNS1 | tensin 1 |
| TPM1 | tropomyosin 1 (alpha) |
| WT1 | Wilms tumor 1 |
| YPEL5 | yippee-like 5 (Drosophila) |
| ZMIZ1 | zinc finger, MIZ-type containing 1 |
| ZNF91 | zinc finger protein 91 |
| Symbol | Name |
|---|---|
| ADRB2 | adrenoceptor beta 2, surface |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
| ASF1B | anti-silencing function 1B histone chaperone |
| CBR3 | carbonyl reductase 3 |
| CCND1 | cyclin D1 |
| CCNF | cyclin F |
| CDC25A | cell division cycle 25A |
| CDC6 | cell division cycle 6 |
| CDK1 | cyclin-dependent kinase 1 |
| CENPU | centromere protein U |
| CHEK2 | checkpoint kinase 2 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP6 | dual specificity phosphatase 6 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 |
| ETV1 | ets variant 1 |
| ETV5 | ets variant 5 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FANCI | Fanconi anemia, complementation group I |
| FOSL1 | FOS-like antigen 1 |
| GAL | galanin/GMAP prepropeptide |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| HMGB2 | high mobility group box 2 |
| ITGB5 | integrin, beta 5 |
| KIAA0101 | KIAA0101 |
| LIG1 | ligase I, DNA, ATP-dependent |
| MCM3 | minichromosome maintenance complex component 3 |
| MCM4 | minichromosome maintenance complex component 4 |
| MT1E | metallothionein 1E |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 |
| NELL2 | NEL-like 2 (chicken) |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 |
| NPY | neuropeptide Y |
| NT5E | 5'-nucleotidase, ecto (CD73) |
| PCNA | proliferating cell nuclear antigen |
| PDE4B | phosphodiesterase 4B, cAMP-specific |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
| PLAU | plasminogen activator, urokinase |
| PNP | purine nucleoside phosphorylase |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
| RAC2 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
| RRM2 | ribonucleotide reductase M2 |
| S100B | S100 calcium binding protein B |
| SCML1 | sex comb on midleg-like 1 (Drosophila) |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 |
| SPP1 | secreted phosphoprotein 1 |
| SPRY2 | sprouty homolog 2 (Drosophila) |
| SPRY4 | sprouty homolog 4 (Drosophila) |
| SRSF7 | serine/arginine-rich splicing factor 7 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 |
| STX1A | syntaxin 1A (brain) |
| TACC3 | transforming, acidic coiled-coil containing protein 3 |
| TFAP2B | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) |
| TIPIN | TIMELESS interacting protein |
| TOP2A | topoisomerase (DNA) II alpha 170kDa |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| ZWINT | ZW10 interacting kinetochore protein |
