BRD-K12502280_TG-101348_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K12502280_TG-101348_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
BEX1 brain expressed, X-linked 1
CFB complement factor B
COL4A5 collagen, type IV, alpha 5
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DDIT4 DNA-damage-inducible transcript 4
LUM lumican
MARCKSL1 MARCKS-like 1
MYO6 myosin VI
NR4A3 nuclear receptor subfamily 4, group A, member 3
ORAI3 ORAI calcium release-activated calcium modulator 3
PLIN2 perilipin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCG5 secretogranin V
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
STK38L serine/threonine kinase 38 like
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TMEM45A transmembrane protein 45A
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
ATP10B ATPase, class V, type 10B
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLU clusterin
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL14 chemokine (C-X-C motif) ligand 14
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DKK1 dickkopf WNT signaling pathway inhibitor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FANCI Fanconi anemia, complementation group I
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
HJURP Holliday junction recognition protein
HOXA10 homeobox A10
HOXB7 homeobox B7
IGFBP4 insulin-like growth factor binding protein 4
JADE2 jade family PHD finger 2
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
MCM4 minichromosome maintenance complex component 4
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEK2 NIMA-related kinase 2
PARP2 poly (ADP-ribose) polymerase 2
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SHCBP1 SHC SH2-domain binding protein 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPP1 secreted phosphoprotein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
Funding