BRD-K12502280_TG-101348_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K12502280_TG-101348_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND2 cyclin D2
CCR7 chemokine (C-C motif) receptor 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHL1 cell adhesion molecule L1-like
COL3A1 collagen, type III, alpha 1
CTH cystathionine gamma-lyase
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
ETV5 ets variant 5
FABP4 fatty acid binding protein 4, adipocyte
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
ITM2A integral membrane protein 2A
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LPL lipoprotein lipase
MTSS1 metastasis suppressor 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
NR2F6 nuclear receptor subfamily 2, group F, member 6
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCDH9 protocadherin 9
PCSK1 proprotein convertase subtilisin/kexin type 1
PHGDH phosphoglycerate dehydrogenase
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS2 regulator of G-protein signaling 2
SIK1 salt-inducible kinase 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TSPAN12 tetraspanin 12
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADM adrenomedullin
ALCAM activated leukocyte cell adhesion molecule
APOA2 apolipoprotein A-II
BEX1 brain expressed, X-linked 1
BMP4 bone morphogenetic protein 4
CD24 CD24 molecule
DKK1 dickkopf WNT signaling pathway inhibitor 1
EVI2A ecotropic viral integration site 2A
FBN2 fibrillin 2
FZD7 frizzled class receptor 7
GPX1 glutathione peroxidase 1
GSTO1 glutathione S-transferase omega 1
IRS1 insulin receptor substrate 1
JUN jun proto-oncogene
KRT19 keratin 19, type I
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MFSD12 major facilitator superfamily domain containing 12
NREP neuronal regeneration related protein
OXA1L oxidase (cytochrome c) assembly 1-like
PDZRN3 PDZ domain containing ring finger 3
SCAND1 SCAN domain containing 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
VSNL1 visinin-like 1
XIST X inactive specific transcript (non-protein coding)
ZNF185 zinc finger protein 185 (LIM domain)
Funding