BRD-K12502280_TG-101348_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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68 genes differentially expressed following the BRD-K12502280_TG-101348_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
BCL2A1 BCL2-related protein A1
BIK BCL2-interacting killer (apoptosis-inducing)
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CD14 CD14 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CGA glycoprotein hormones, alpha polypeptide
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLU clusterin
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CST7 cystatin F (leukocystatin)
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
GPER1 G protein-coupled estrogen receptor 1
KRT7 keratin 7, type II
KRT8 keratin 8, type II
MAPT microtubule-associated protein tau
MCF2L MCF.2 cell line derived transforming sequence-like
MXRA5 matrix-remodelling associated 5
MYOF myoferlin
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
TRAP1 TNF receptor-associated protein 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTA2 actin, alpha 2, smooth muscle, aorta
BEX1 brain expressed, X-linked 1
CCP110 centriolar coiled coil protein 110kDa
CGRRF1 cell growth regulator with ring finger domain 1
CRISP3 cysteine-rich secretory protein 3
CRP C-reactive protein, pentraxin-related
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DSE dermatan sulfate epimerase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGB fibrinogen beta chain
GDF15 growth differentiation factor 15
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GOLM1 golgi membrane protein 1
GSTA1 glutathione S-transferase alpha 1
IFI44L interferon-induced protein 44-like
IGHD immunoglobulin heavy constant delta
MAOA monoamine oxidase A
MGLL monoglyceride lipase
NDNF neuron-derived neurotrophic factor
NEFL neurofilament, light polypeptide
NINJ2 ninjurin 2
NPTX2 neuronal pentraxin II
PBX3 pre-B-cell leukemia homeobox 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RTN1 reticulon 1
SDC1 syndecan 1
SIK1 salt-inducible kinase 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
SRGN serglycin
SSBP2 single-stranded DNA binding protein 2
TBX2 T-box 2
TIAM1 T-cell lymphoma invasion and metastasis 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP6NL USP6 N-terminal like