BRD-K12787259_CX-5461_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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79 genes differentially expressed following the BRD-K12787259_CX-5461_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP7 A kinase (PRKA) anchor protein 7
ARG2 arginase 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CBR1 carbonyl reductase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CST1 cystatin SN
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP4 fatty acid binding protein 4, adipocyte
FDXR ferredoxin reductase
FGFR2 fibroblast growth factor receptor 2
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6B glycoprotein M6B
GSTP1 glutathione S-transferase pi 1
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
KRT23 keratin 23, type I
LYPD1 LY6/PLAUR domain containing 1
MRPL33 mitochondrial ribosomal protein L33
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PALLD palladin, cytoskeletal associated protein
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PON2 paraoxonase 2
RBKS ribokinase
RPS27L ribosomal protein S27-like
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SMAD3 SMAD family member 3
SQSTM1 sequestosome 1
TP53I3 tumor protein p53 inducible protein 3
TRIM2 tripartite motif containing 2

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANPEP alanyl (membrane) aminopeptidase
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHERP calcium homeostasis endoplasmic reticulum protein
COL15A1 collagen, type XV, alpha 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
EMP1 epithelial membrane protein 1
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HLA-DRA major histocompatibility complex, class II, DR alpha
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IPO13 importin 13
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MGP matrix Gla protein
MUC4 mucin 4, cell surface associated
NMU neuromedin U
NUPR1 nuclear protein, transcriptional regulator, 1
PDZRN3 PDZ domain containing ring finger 3
RNF130 ring finger protein 130
S100A8 S100 calcium binding protein A8
SFRP1 secreted frizzled-related protein 1
SOX11 SRY (sex determining region Y)-box 11
SPON1 spondin 1, extracellular matrix protein
STMN1 stathmin 1
TSPYL5 TSPY-like 5
ZBTB18 zinc finger and BTB domain containing 18