BRD-K12787259_CX-5461_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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82 genes differentially expressed following the BRD-K12787259_CX-5461_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATPIF1 ATPase inhibitory factor 1
CGRRF1 cell growth regulator with ring finger domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK1 checkpoint kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTGF connective tissue growth factor
CYFIP2 cytoplasmic FMR1 interacting protein 2
DLC1 DLC1 Rho GTPase activating protein
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
ENO2 enolase 2 (gamma, neuronal)
EPHB2 EPH receptor B2
EREG epiregulin
FLRT3 fibronectin leucine rich transmembrane protein 3
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HES1 hes family bHLH transcription factor 1
HSPB1 heat shock 27kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
ITGA6 integrin, alpha 6
LAPTM4B lysosomal protein transmembrane 4 beta
MELK maternal embryonic leucine zipper kinase
MMP3 matrix metallopeptidase 3
MX2 MX dynamin-like GTPase 2
NAV2 neuron navigator 2
PDGFD platelet derived growth factor D
PDLIM5 PDZ and LIM domain 5
PLS3 plastin 3
PRDX2 peroxiredoxin 2
QPCT glutaminyl-peptide cyclotransferase
RCAN1 regulator of calcineurin 1
RPS27L ribosomal protein S27-like
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAMD4A sterile alpha motif domain containing 4A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPRY2 sprouty homolog 2 (Drosophila)
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
STOM stomatin
STXBP1 syntaxin binding protein 1
TFPI2 tissue factor pathway inhibitor 2
TNC tenascin C
TRIM2 tripartite motif containing 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADA adenosine deaminase
AIM1 absent in melanoma 1
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ASS1 argininosuccinate synthase 1
BASP1 brain abundant, membrane attached signal protein 1
BID BH3 interacting domain death agonist
CA12 carbonic anhydrase XII
CFD complement factor D (adipsin)
CSTA cystatin A (stefin A)
DSP desmoplakin
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FHL1 four and a half LIM domains 1
FKBP5 FK506 binding protein 5
GLIPR1 GLI pathogenesis-related 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HCAR3 hydroxycarboxylic acid receptor 3
KRT18 keratin 18, type I
LTF lactotransferrin
MAOB monoamine oxidase B
MAPT microtubule-associated protein tau
MYH11 myosin, heavy chain 11, smooth muscle
NR1H2 nuclear receptor subfamily 1, group H, member 2
PIP prolactin-induced protein
PRKCB protein kinase C, beta
PRPF4 pre-mRNA processing factor 4
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBPMS RNA binding protein with multiple splicing
REEP1 receptor accessory protein 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SCGB1D2 secretoglobin, family 1D, member 2
TMEM100 transmembrane protein 100
TNFAIP8 tumor necrosis factor, alpha-induced protein 8