BRD-K12867552_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K12867552_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C1QB complement component 1, q subcomponent, B chain
C3AR1 complement component 3a receptor 1
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CLIC4 chloride intracellular channel 4
CPA3 carboxypeptidase A3 (mast cell)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK1 death-associated protein kinase 1
DCN decorin
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSTN destrin (actin depolymerizing factor)
EAF2 ELL associated factor 2
EIF5A eukaryotic translation initiation factor 5A
EZR ezrin
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FYB FYN binding protein
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MGST3 microsomal glutathione S-transferase 3
MSMO1 methylsterol monooxygenase 1
MTUS1 microtubule associated tumor suppressor 1
NAGK N-acetylglucosamine kinase
NSDHL NAD(P) dependent steroid dehydrogenase-like
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLA2G15 phospholipase A2, group XV
RAD9A RAD9 homolog A (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS10 regulator of G-protein signaling 10
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPON1 spondin 1, extracellular matrix protein
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STX7 syntaxin 7
TFRC transferrin receptor
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TYROBP TYRO protein tyrosine kinase binding protein
VNN1 vanin 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADORA2B adenosine A2b receptor
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BEX1 brain expressed, X-linked 1
CADM1 cell adhesion molecule 1
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CTBP1 C-terminal binding protein 1
DUSP4 dual specificity phosphatase 4
F3 coagulation factor III (thromboplastin, tissue factor)
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GSAP gamma-secretase activating protein
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
IGFBP7 insulin-like growth factor binding protein 7
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KLK10 kallikrein-related peptidase 10
KPNB1 karyopherin (importin) beta 1
KRT5 keratin 5, type II
LAMB1 laminin, beta 1
LPL lipoprotein lipase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MICALL1 MICAL-like 1
MOK MOK protein kinase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSL1 obscurin-like 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PUF60 poly-U binding splicing factor 60KDa
RCN1 reticulocalbin 1, EF-hand calcium binding domain
S100A2 S100 calcium binding protein A2
SFRP1 secreted frizzled-related protein 1
SPATA20 spermatogenesis associated 20
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TGFBI transforming growth factor, beta-induced, 68kDa
TWIST1 twist family bHLH transcription factor 1
VEGFA vascular endothelial growth factor A
ZBTB38 zinc finger and BTB domain containing 38
ZIC1 Zic family member 1