BRD-K12867552_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

311 genes differentially expressed following the BRD-K12867552_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD3 abhydrolase domain containing 3
ACOT7 acyl-CoA thioesterase 7
ADCY9 adenylate cyclase 9
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ASMTL acetylserotonin O-methyltransferase-like
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C18ORF8 chromosome 18 open reading frame 8
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALML4 calmodulin-like 4
CCDC28A coiled-coil domain containing 28A
CCNE1 cyclin E1
CD47 CD47 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEMIP cell migration inducing protein, hyaluronan binding
CIB1 calcium and integrin binding 1 (calmyrin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLIC5 chloride intracellular channel 5
COG5 component of oligomeric golgi complex 5
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CPM carboxypeptidase M
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN3 endothelin 3
EPAS1 endothelial PAS domain protein 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
EZR ezrin
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GMCL1 germ cell-less, spermatogenesis associated 1
GRK5 G protein-coupled receptor kinase 5
GSDMB gasdermin B
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HPSE heparanase
HRSP12 heat-responsive protein 12
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA1A heat shock 70kDa protein 1A
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL2RG interleukin 2 receptor, gamma
IL32 interleukin 32
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
KLHL24 kelch-like family member 24
L1CAM L1 cell adhesion molecule
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
LGMN legumain
LMO3 LIM domain only 3 (rhombotin-like 2)
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPIN1 lipin 1
LPXN leupaxin
MALL mal, T-cell differentiation protein-like
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MGST3 microsomal glutathione S-transferase 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MSMO1 methylsterol monooxygenase 1
MSN moesin
MVP major vault protein
MXRA7 matrix-remodelling associated 7
NCAM1 neural cell adhesion molecule 1
NDN necdin, melanoma antigen (MAGE) family member
NEU1 sialidase 1 (lysosomal sialidase)
NLRP2 NLR family, pyrin domain containing 2
NPC1 Niemann-Pick disease, type C1
NPTX2 neuronal pentraxin II
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
NXN nucleoredoxin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PCSK5 proprotein convertase subtilisin/kexin type 5
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PNMA2 paraneoplastic Ma antigen 2
POLB polymerase (DNA directed), beta
POR P450 (cytochrome) oxidoreductase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS3 protease, serine, 3
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB29 RAB29, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAP1GAP RAP1 GTPase activating protein
RAP2A RAP2A, member of RAS oncogene family
RFTN1 raftlin, lipid raft linker 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
ROGDI rogdi homolog (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTSSA serine palmitoyltransferase, small subunit A
SRGN serglycin
SST somatostatin
STAT1 signal transducer and activator of transcription 1, 91kDa
STK17A serine/threonine kinase 17a
STXBP1 syntaxin binding protein 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBPL1 TBP-like 1
TCEAL2 transcription elongation factor A (SII)-like 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TLE4 transducin-like enhancer of split 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM41B transmembrane protein 41B
TMSB15A thymosin beta 15a
TNS1 tensin 1
TPST1 tyrosylprotein sulfotransferase 1
TPST2 tyrosylprotein sulfotransferase 2
TRIM2 tripartite motif containing 2
TST thiosulfate sulfurtransferase (rhodanese)
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VIM vimentin
WDR47 WD repeat domain 47
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAM28 ADAM metallopeptidase domain 28
ADIRF adipogenesis regulatory factor
AKAP8 A kinase (PRKA) anchor protein 8
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARGLU1 arginine and glutamate rich 1
ARID1A AT rich interactive domain 1A (SWI-like)
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CD24 CD24 molecule
CKAP4 cytoskeleton-associated protein 4
CLU clusterin
CTBP1 C-terminal binding protein 1
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ESR1 estrogen receptor 1
FOXA1 forkhead box A1
FXYD3 FXYD domain containing ion transport regulator 3
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IGF1R insulin-like growth factor 1 receptor
IL1RN interleukin 1 receptor antagonist
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INTS3 integrator complex subunit 3
IRAK1 interleukin-1 receptor-associated kinase 1
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KYNU kynureninase
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MRPS30 mitochondrial ribosomal protein S30
MSL1 male-specific lethal 1 homolog (Drosophila)
MSMB microseminoprotein, beta-
MTMR1 myotubularin related protein 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
MYOF myoferlin
NBN nibrin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PRR7 proline rich 7 (synaptic)
PSCA prostate stem cell antigen
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
RAB25 RAB25, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RBMX RNA binding motif protein, X-linked
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SENP6 SUMO1/sentrin specific peptidase 6
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFPQ splicing factor proline/glutamine-rich
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPRY2 sprouty homolog 2 (Drosophila)
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX2 T-box 2
TCERG1 transcription elongation regulator 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TP53 tumor protein p53
TP63 tumor protein p63
TPBG trophoblast glycoprotein
TRIM29 tripartite motif containing 29
TSKU tsukushi, small leucine rich proteoglycan
TTC39A tetratricopeptide repeat domain 39A
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYM2 zinc finger, MYM-type 2
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