BRD-K12906962_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K12906962_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ANKRD10 ankyrin repeat domain 10
AREG amphiregulin
BHLHE40 basic helix-loop-helix family, member e40
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C8ORF4 chromosome 8 open reading frame 4
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CHRDL1 chordin-like 1
CLU clusterin
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DPT dermatopontin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADS1 fatty acid desaturase 1
FN1 fibronectin 1
FOXO3 forkhead box O3
H2AFV H2A histone family, member V
HBP1 HMG-box transcription factor 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
KDM3A lysine (K)-specific demethylase 3A
LDLR low density lipoprotein receptor
MSMO1 methylsterol monooxygenase 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
PALLD palladin, cytoskeletal associated protein
PER1 period circadian clock 1
PPAP2C phosphatidic acid phosphatase type 2C
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFN stratifin
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
TACSTD2 tumor-associated calcium signal transducer 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1

decreased expression

Symbol Name
CLEC2B C-type lectin domain family 2, member B
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DLK1 delta-like 1 homolog (Drosophila)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
PFKP phosphofructokinase, platelet
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPRY2 sprouty homolog 2 (Drosophila)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WT1 Wilms tumor 1
Funding