BRD-K13046565_(S)-tert-butyl 3-(4-benzoylphenyl)-1-oxo-1-(prop-2-ynylamino)propan-2-ylcarbamate CAL-NIDDK-037_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K13046565_(S)-tert-butyl 3-(4-benzoylphenyl)-1-oxo-1-(prop-2-ynylamino)propan-2-ylcarbamate CAL-NIDDK-037_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA10 annexin A10
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CANX calnexin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CRELD2 cysteine-rich with EGF-like domains 2
CTTN cortactin
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP6 dual specificity phosphatase 6
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FOLR1 folate receptor 1 (adult)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
LOX lysyl oxidase
MAGT1 magnesium transporter 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MFAP5 microfibrillar associated protein 5
MSLN mesothelin
NPTX2 neuronal pentraxin II
NUCB2 nucleobindin 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PDZD2 PDZ domain containing 2
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SDF2L1 stromal cell-derived factor 2-like 1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
TACSTD2 tumor-associated calcium signal transducer 2
TIMP3 TIMP metallopeptidase inhibitor 3
TOB1 transducer of ERBB2, 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2A1 BCL2-related protein A1
C2CD2 C2 calcium-dependent domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DLC1 DLC1 Rho GTPase activating protein
GATA2 GATA binding protein 2
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
LY75 lymphocyte antigen 75
MAN1C1 mannosidase, alpha, class 1C, member 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MNDA myeloid cell nuclear differentiation antigen
MTERF3 mitochondrial transcription termination factor 3
MYLK myosin light chain kinase
NDN necdin, melanoma antigen (MAGE) family member
NELL2 NEL-like 2 (chicken)
NID2 nidogen 2 (osteonidogen)
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRR7 proline rich 7 (synaptic)
SEPP1 selenoprotein P, plasma, 1
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
Funding