BRD-K13087974_D3943_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K13087974_D3943_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AQP9 aquaporin 9
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCHE butyrylcholinesterase
CCDC86 coiled-coil domain containing 86
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
EFS embryonal Fyn-associated substrate
FAM129A family with sequence similarity 129, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MME membrane metallo-endopeptidase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRAME preferentially expressed antigen in melanoma
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPTBN1 spectrin, beta, non-erythrocytic 1
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
BLNK B-cell linker
C8ORF4 chromosome 8 open reading frame 4
CAV1 caveolin 1, caveolae protein, 22kDa
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLIC4 chloride intracellular channel 4
COL10A1 collagen, type X, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DLX2 distal-less homeobox 2
DPYSL2 dihydropyrimidinase-like 2
EFNB2 ephrin-B2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAM69A family with sequence similarity 69, member A
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MEF2C myocyte enhancer factor 2C
MSLN mesothelin
NPY1R neuropeptide Y receptor Y1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
OAT ornithine aminotransferase
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM3 PDZ and LIM domain 3
RHOBTB3 Rho-related BTB domain containing 3
S100P S100 calcium binding protein P
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SOX9 SRY (sex determining region Y)-box 9
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TOX3 TOX high mobility group box family member 3
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
VCAM1 vascular cell adhesion molecule 1
ZW10 zw10 kinetochore protein
Funding