BRD-K13094524_PFI-1_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K13094524_PFI-1_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
BLNK B-cell linker
CA2 carbonic anhydrase II
CALCA calcitonin-related polypeptide alpha
CD164 CD164 molecule, sialomucin
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DSP desmoplakin
FOLR1 folate receptor 1 (adult)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
LUC7L3 LUC7-like 3 (S. cerevisiae)
NARFL nuclear prelamin A recognition factor-like
OLFM4 olfactomedin 4
PEG10 paternally expressed 10
PLS1 plastin 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SFRP4 secreted frizzled-related protein 4
TFF3 trefoil factor 3 (intestinal)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CBR3 carbonyl reductase 3
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CP ceruloplasmin (ferroxidase)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
EDN1 endothelin 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGF epidermal growth factor
EIF5 eukaryotic translation initiation factor 5
FABP7 fatty acid binding protein 7, brain
HIP1 huntingtin interacting protein 1
HOPX HOP homeobox
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
MSLN mesothelin
MSMB microseminoprotein, beta-
MYBPC1 myosin binding protein C, slow type
OLFML3 olfactomedin-like 3
PDGFC platelet derived growth factor C
PIP prolactin-induced protein
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
QPRT quinolinate phosphoribosyltransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RFTN1 raftlin, lipid raft linker 1
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SPARCL1 SPARC-like 1 (hevin)
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TPM1 tropomyosin 1 (alpha)
TYRP1 tyrosinase-related protein 1
VWF von Willebrand factor
XPO7 exportin 7
Funding