BRD-K13094524_PFI-1_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K13094524_PFI-1_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
CCDC92 coiled-coil domain containing 92
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GPATCH8 G patch domain containing 8
HIST1H1C histone cluster 1, H1c
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KRT7 keratin 7, type II
MELK maternal embryonic leucine zipper kinase
MT1X metallothionein 1X
MT2A metallothionein 2A
MYO6 myosin VI
NPIPB3 nuclear pore complex interacting protein family, member B3
OAT ornithine aminotransferase
OLIG2 oligodendrocyte lineage transcription factor 2
PALLD palladin, cytoskeletal associated protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLA2G15 phospholipase A2, group XV
PROM1 prominin 1
PVALB parvalbumin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SIK1 salt-inducible kinase 1
SQSTM1 sequestosome 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TJP2 tight junction protein 2
TTC3 tetratricopeptide repeat domain 3
VDAC1 voltage-dependent anion channel 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ARG1 arginase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CCDC86 coiled-coil domain containing 86
CD200 CD200 molecule
CD24 CD24 molecule
CD27 CD27 molecule
CD44 CD44 molecule (Indian blood group)
CD48 CD48 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EVI2A ecotropic viral integration site 2A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FGF13 fibroblast growth factor 13
FGFBP1 fibroblast growth factor binding protein 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GLUL glutamate-ammonia ligase
GPR88 G protein-coupled receptor 88
GSTA1 glutathione S-transferase alpha 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HP haptoglobin
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGLJ3 immunoglobulin lambda joining 3
IPO13 importin 13
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LPAR6 lysophosphatidic acid receptor 6
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MAPK13 mitogen-activated protein kinase 13
MFAP2 microfibrillar-associated protein 2
MGP matrix Gla protein
MTA1 metastasis associated 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OLFM4 olfactomedin 4
PCOLCE procollagen C-endopeptidase enhancer
PEX11A peroxisomal biogenesis factor 11 alpha
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SDC2 syndecan 2
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STC1 stanniocalcin 1
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
Funding