BRD-K13169950_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K13169950_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AK4 adenylate kinase 4
ARC activity-regulated cytoskeleton-associated protein
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK5 docking protein 5
EGR1 early growth response 1
FCGBP Fc fragment of IgG binding protein
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
GMPR guanosine monophosphate reductase
HBP1 HMG-box transcription factor 1
HEPH hephaestin
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BK histone cluster 1, H2bk
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MEG3 maternally expressed 3 (non-protein coding)
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OSER1 oxidative stress responsive serine-rich 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNMT RNA (guanine-7-) methyltransferase
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC3 syndecan 3
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOS1 son of sevenless homolog 1 (Drosophila)
SPON1 spondin 1, extracellular matrix protein
SQSTM1 sequestosome 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
WISP2 WNT1 inducible signaling pathway protein 2
WT1 Wilms tumor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADGRG6 adhesion G protein-coupled receptor G6
AGTR1 angiotensin II receptor, type 1
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
ANAPC13 anaphase promoting complex subunit 13
AREG amphiregulin
AURKA aurora kinase A
B3GNT1
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CENPA centromere protein A
CIRBP cold inducible RNA binding protein
COL9A3 collagen, type IX, alpha 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSC cathepsin C
DCPS decapping enzyme, scavenger
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA3 EPH receptor A3
EREG epiregulin
ERLIN1 ER lipid raft associated 1
FXYD2 FXYD domain containing ion transport regulator 2
GRB14 growth factor receptor-bound protein 14
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXA5 homeobox A5
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LGALS1 lectin, galactoside-binding, soluble, 1
MGLL monoglyceride lipase
NPM3 nucleophosmin/nucleoplasmin 3
NRP1 neuropilin 1
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SMYD2 SET and MYND domain containing 2
SPTSSA serine palmitoyltransferase, small subunit A
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)