BRD-K13169950_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K13169950_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD163 CD163 molecule
CD52 CD52 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLGN calmegin
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPM carboxypeptidase M
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FASTKD5 FAST kinase domains 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GLIPR1 GLI pathogenesis-related 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
LDHB lactate dehydrogenase B
LDLR low density lipoprotein receptor
LXN latexin
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MT1M metallothionein 1M
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMP22 peripheral myelin protein 22
PRR7 proline rich 7 (synaptic)
PTPRE protein tyrosine phosphatase, receptor type, E
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RIOK3 RIO kinase 3
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SRGN serglycin
STEAP1 six transmembrane epithelial antigen of the prostate 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
BEX1 brain expressed, X-linked 1
CCND1 cyclin D1
CD24 CD24 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COBLL1 cordon-bleu WH2 repeat protein-like 1
CP ceruloplasmin (ferroxidase)
ERBB2 erb-b2 receptor tyrosine kinase 2
GRB14 growth factor receptor-bound protein 14
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IRS1 insulin receptor substrate 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RGS1 regulator of G-protein signaling 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SOX11 SRY (sex determining region Y)-box 11
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB tubulin, beta class I
Funding