BRD-K13390322_AT-7519_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

172 genes differentially expressed following the BRD-K13390322_AT-7519_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
APLP2 amyloid beta (A4) precursor-like protein 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BPIFA1 BPI fold containing family A, member 1
BTG2 BTG family, member 2
C3 complement component 3
C7 complement component 7
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL8 chemokine (C-C motif) ligand 8
CD48 CD48 molecule
CD52 CD52 molecule
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CPE carboxypeptidase E
CTSZ cathepsin Z
CTTN cortactin
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DPT dermatopontin
DUSP1 dual specificity phosphatase 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GAS6 growth arrest-specific 6
GLIPR1 GLI pathogenesis-related 1
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IL7R interleukin 7 receptor
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
LAMP3 lysosomal-associated membrane protein 3
LPPR4 lipid phosphate phosphatase-related protein type 4
LTB lymphotoxin beta (TNF superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
METTL7A methyltransferase like 7A
MMP1 matrix metallopeptidase 1
MSLN mesothelin
MT1E metallothionein 1E
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
PALLD palladin, cytoskeletal associated protein
PDE2A phosphodiesterase 2A, cGMP-stimulated
PECAM1 platelet/endothelial cell adhesion molecule 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTPRC protein tyrosine phosphatase, receptor type, C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SLPI secretory leukocyte peptidase inhibitor
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN7 tetraspanin 7
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CCNA2 cyclin A2
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CLTA clathrin, light chain A
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL5 chemokine (C-X-C motif) ligand 5
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EDNRB endothelin receptor type B
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
FZD7 frizzled class receptor 7
GPSM2 G-protein signaling modulator 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KLHL9 kelch-like family member 9
KRT7 keratin 7, type II
LPAR1 lysophosphatidic acid receptor 1
LTF lactotransferrin
LXN latexin
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MPRIP myosin phosphatase Rho interacting protein
NEK7 NIMA-related kinase 7
NMI N-myc (and STAT) interactor
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OXA1L oxidase (cytochrome c) assembly 1-like
PBK PDZ binding kinase
PDE4B phosphodiesterase 4B, cAMP-specific
PDHX pyruvate dehydrogenase complex, component X
PDLIM5 PDZ and LIM domain 5
PDS5A PDS5 cohesin associated factor A
PKM pyruvate kinase, muscle
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
RIN2 Ras and Rab interactor 2
RPL36AL ribosomal protein L36a-like
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
SMC4 structural maintenance of chromosomes 4
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR4 toll-like receptor 4
TNC tenascin C
TOX3 TOX high mobility group box family member 3
TPX2 TPX2, microtubule-associated
TSPYL5 TSPY-like 5
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
VCAN versican
WWTR1 WW domain containing transcription regulator 1
ZIC1 Zic family member 1
ZMIZ1 zinc finger, MIZ-type containing 1
Funding