BRD-K13390322_AT-7519_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-K13390322_AT-7519_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
ACOX1 acyl-CoA oxidase 1, palmitoyl
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
ANKRD36B ankyrin repeat domain 36B
ANXA3 annexin A3
AQP9 aquaporin 9
ARL3 ADP-ribosylation factor-like 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
C1QTNF3 C1q and tumor necrosis factor related protein 3
CD36 CD36 molecule (thrombospondin receptor)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CETN2 centrin, EF-hand protein, 2
CFD complement factor D (adipsin)
CFH complement factor H
CLC Charcot-Leyden crystal galectin
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSTA cystatin A (stefin A)
CXCL13 chemokine (C-X-C motif) ligand 13
CYBB cytochrome b-245, beta polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DPT dermatopontin
DSG2 desmoglein 2
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GDE1 glycerophosphodiester phosphodiesterase 1
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFITM3 interferon induced transmembrane protein 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITM2A integral membrane protein 2A
KIAA0226L KIAA0226-like
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LRRC15 leucine rich repeat containing 15
MMP9 matrix metallopeptidase 9
MSMB microseminoprotein, beta-
MXRA5 matrix-remodelling associated 5
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCF4 neutrophil cytosolic factor 4, 40kDa
NDNF neuron-derived neurotrophic factor
NEFH neurofilament, heavy polypeptide
NPIPB3 nuclear pore complex interacting protein family, member B3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCI protein kinase C, iota
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RRAGD Ras-related GTP binding D
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TMEM260 transmembrane protein 260
TNS1 tensin 1
TPD52 tumor protein D52
UROS uroporphyrinogen III synthase
WISP2 WNT1 inducible signaling pathway protein 2

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACVR1B activin A receptor, type IB
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
APOLD1 apolipoprotein L domain containing 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BCL10 B-cell CLL/lymphoma 10
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
CA12 carbonic anhydrase XII
CCNE2 cyclin E2
CCNF cyclin F
CCNL1 cyclin L1
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSNK1E casein kinase 1, epsilon
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DDIT4 DNA-damage-inducible transcript 4
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EDN1 endothelin 1
EPS8 epidermal growth factor receptor pathway substrate 8
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASTKD5 FAST kinase domains 5
FBXO5 F-box protein 5
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
LMNB1 lamin B1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MSX1 msh homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP153 nucleoporin 153kDa
NUP62 nucleoporin 62kDa
PDGFA platelet-derived growth factor alpha polypeptide
PDHX pyruvate dehydrogenase complex, component X
PDLIM4 PDZ and LIM domain 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SALL1 spalt-like transcription factor 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMAGP small cell adhesion glycoprotein
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
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