BRD-K13390322_AT-7519_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-K13390322_AT-7519_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
AMT aminomethyltransferase
ANPEP alanyl (membrane) aminopeptidase
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
CCL20 chemokine (C-C motif) ligand 20
CD59 CD59 molecule, complement regulatory protein
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CLGN calmegin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DIRAS3 DIRAS family, GTP-binding RAS-like 3
EIF5A eukaryotic translation initiation factor 5A
FABP1 fatty acid binding protein 1, liver
FAM162A family with sequence similarity 162, member A
FOLR1 folate receptor 1 (adult)
GTF2H5 general transcription factor IIH, polypeptide 5
HP haptoglobin
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSPA8 heat shock 70kDa protein 8
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KIAA0226L KIAA0226-like
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LGMN legumain
LOX lysyl oxidase
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTB lymphotoxin beta (TNF superfamily, member 3)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP1 matrix metallopeptidase 1
MPP1 membrane protein, palmitoylated 1, 55kDa
MSN moesin
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NMU neuromedin U
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PFKM phosphofructokinase, muscle
PGK1 phosphoglycerate kinase 1
PHKB phosphorylase kinase, beta
PLAGL1 pleiomorphic adenoma gene-like 1
PLS3 plastin 3
PRDX3 peroxiredoxin 3
PSPH phosphoserine phosphatase
QDPR quinoid dihydropteridine reductase
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SEPT10 septin 10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SKP1 S-phase kinase-associated protein 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM45A transmembrane protein 45A
TPGS2 tubulin polyglutamylase complex subunit 2
TPM2 tropomyosin 2 (beta)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
USO1 USO1 vesicle transport factor

decreased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK AHNAK nucleoprotein
AKAP8 A kinase (PRKA) anchor protein 8
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP12 Rho GTPase activating protein 12
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASF1A anti-silencing function 1A histone chaperone
ATF3 activating transcription factor 3
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BLCAP bladder cancer associated protein
CADM1 cell adhesion molecule 1
CCL5 chemokine (C-C motif) ligand 5
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CEP350 centrosomal protein 350kDa
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
COIL coilin
COL15A1 collagen, type XV, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DBF4 DBF4 zinc finger
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EGR2 early growth response 2
EIF5 eukaryotic translation initiation factor 5
FAM208B family with sequence similarity 208, member B
FASTKD5 FAST kinase domains 5
FBXL14 F-box and leucine-rich repeat protein 14
FOXO3 forkhead box O3
FUBP1 far upstream element (FUSE) binding protein 1
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GTF2B general transcription factor IIB
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
KDM5B lysine (K)-specific demethylase 5B
KRT7 keratin 7, type II
KYNU kynureninase
LPAR6 lysophosphatidic acid receptor 6
LPIN1 lipin 1
LRRC8B leucine rich repeat containing 8 family, member B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED13 mediator complex subunit 13
MGP matrix Gla protein
MSL2 male-specific lethal 2 homolog (Drosophila)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCK1 NCK adaptor protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NOL11 nucleolar protein 11
NOTCH2 notch 2
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
OSR2 odd-skipped related transciption factor 2
PARP2 poly (ADP-ribose) polymerase 2
PCF11 PCF11 cleavage and polyadenylation factor subunit
PER2 period circadian clock 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POGK pogo transposable element with KRAB domain
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRR15L proline rich 15-like
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRO protein tyrosine phosphatase, receptor type, O
QKI QKI, KH domain containing, RNA binding
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RBMS1 RNA binding motif, single stranded interacting protein 1
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RHOF ras homolog family member F (in filopodia)
RNF38 ring finger protein 38
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RXRA retinoid X receptor, alpha
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SERTAD2 SERTA domain containing 2
SERTAD3 SERTA domain containing 3
SESN1 sestrin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SMG8 SMG8 nonsense mediated mRNA decay factor
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TOB1 transducer of ERBB2, 1
TRIM33 tripartite motif containing 33
TSKU tsukushi, small leucine rich proteoglycan
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP1 ubiquitin specific peptidase 1
VEZF1 vascular endothelial zinc finger 1
VGLL4 vestigial-like family member 4
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
ZNHIT6 zinc finger, HIT-type containing 6
Funding