BRD-K13390322_AT-7519_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-K13390322_AT-7519_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
AOC3 amine oxidase, copper containing 3
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD3D CD3d molecule, delta (CD3-TCR complex)
CD48 CD48 molecule
CD84 CD84 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CES1 carboxylesterase 1
CETN2 centrin, EF-hand protein, 2
CFD complement factor D (adipsin)
CKB creatine kinase, brain
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL6A1 collagen, type VI, alpha 1
CPE carboxypeptidase E
CTSC cathepsin C
CTTN cortactin
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPT dermatopontin
DSP desmoplakin
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP4 fatty acid binding protein 4, adipocyte
FAM107A family with sequence similarity 107, member A
FBLN1 fibulin 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
FOXF1 forkhead box F1
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HES1 hes family bHLH transcription factor 1
HEXA hexosaminidase A (alpha polypeptide)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN5 high mobility group nucleosome binding domain 5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMP3 lysosomal-associated membrane protein 3
LOC100272216 uncharacterized LOC100272216
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP4 microfibrillar-associated protein 4
MMP9 matrix metallopeptidase 9
NME1 NME/NM23 nucleoside diphosphate kinase 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PERP PERP, TP53 apoptosis effector
PGK1 phosphoglycerate kinase 1
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PROS1 protein S (alpha)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SPARCL1 SPARC-like 1 (hevin)
STAB1 stabilin 1
STC1 stanniocalcin 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM14B transmembrane protein 14B
TMSB15A thymosin beta 15a
TNS1 tensin 1
TP53TG1 TP53 target 1 (non-protein coding)
TPGS2 tubulin polyglutamylase complex subunit 2
TRAC T cell receptor alpha constant
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TTC3 tetratricopeptide repeat domain 3
TYROBP TYRO protein tyrosine kinase binding protein
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AHNAK AHNAK nucleoprotein
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARF6 ADP-ribosylation factor 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C2CD5 C2 calcium-dependent domain containing 5
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CGRRF1 cell growth regulator with ring finger domain 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTBP2 C-terminal binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMBP dynamin binding protein
ELF5 E74-like factor 5 (ets domain transcription factor)
EREG epiregulin
FBL fibrillarin
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCH1 GTP cyclohydrolase 1
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
JADE2 jade family PHD finger 2
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LMNB1 lamin B1
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
MRPS30 mitochondrial ribosomal protein S30
MYO10 myosin X
NET1 neuroepithelial cell transforming 1
NOTCH2 notch 2
OGFRL1 opioid growth factor receptor-like 1
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PFKP phosphofructokinase, platelet
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PROM1 prominin 1
PSD3 pleckstrin and Sec7 domain containing 3
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RNPS1 RNA binding protein S1, serine-rich domain
S100A12 S100 calcium binding protein A12
SCAND1 SCAN domain containing 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAD3 SMAD family member 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMPO thymopoietin
TRAM2 translocation associated membrane protein 2
TRIM2 tripartite motif containing 2
TXLNA taxilin alpha
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding