BRD-K13646352_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K13646352_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCL6 B-cell CLL/lymphoma 6
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
FKBP11 FK506 binding protein 11, 19 kDa
GAB2 GRB2-associated binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IRF4 interferon regulatory factor 4
LINC00341 long intergenic non-protein coding RNA 341
LONP2 lon peptidase 2, peroxisomal
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCOLN1 mucolipin 1
NEFM neurofilament, medium polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCP4 Purkinje cell protein 4
PON3 paraoxonase 3
PRSS2 protease, serine, 2 (trypsin 2)
PRSS21 protease, serine, 21 (testisin)
PSAT1 phosphoserine aminotransferase 1
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SRGN serglycin
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCF4 transcription factor 4
TCL1A T-cell leukemia/lymphoma 1A
TES testin LIM domain protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THY1 Thy-1 cell surface antigen
TPBG trophoblast glycoprotein
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
BPGM 2,3-bisphosphoglycerate mutase
CCL5 chemokine (C-C motif) ligand 5
CCNB1 cyclin B1
CCNE2 cyclin E2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN4 claudin 4
CTSW cathepsin W
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA3 EPH receptor A3
FYB FYN binding protein
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
H3F3B H3 histone, family 3B (H3.3B)
HDAC9 histone deacetylase 9
HOMER1 homer scaffolding protein 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
IL32 interleukin 32
IL7R interleukin 7 receptor
IPO13 importin 13
JAG1 jagged 1
JMJD6 jumonji domain containing 6
KLHL21 kelch-like family member 21
LGALS3 lectin, galactoside-binding, soluble, 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MYH11 myosin, heavy chain 11, smooth muscle
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PDLIM3 PDZ and LIM domain 3
PGBD5 piggyBac transposable element derived 5
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRDX2 peroxiredoxin 2
RHOB ras homolog family member B
RPIA ribose 5-phosphate isomerase A
SATB2 SATB homeobox 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SMAD7 SMAD family member 7
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
TGFA transforming growth factor, alpha
THBS4 thrombospondin 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
VAMP8 vesicle-associated membrane protein 8
VLDLR very low density lipoprotein receptor
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)