BRD-K13662825_dinaciclib_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

248 genes differentially expressed following the BRD-K13662825_dinaciclib_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADIPOQ adiponectin, C1Q and collagen domain containing
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATXN1 ataxin 1
BACE2 beta-site APP-cleaving enzyme 2
C1QTNF3 C1q and tumor necrosis factor related protein 3
CADM1 cell adhesion molecule 1
CD200 CD200 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CKLF chemokine-like factor
CLU clusterin
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COX17 COX17 cytochrome c oxidase copper chaperone
COX7B cytochrome c oxidase subunit VIIb
CPD carboxypeptidase D
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CTSD cathepsin D
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUSP1 dual specificity phosphatase 1
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
ECM1 extracellular matrix protein 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EFNB2 ephrin-B2
EGR1 early growth response 1
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM198B family with sequence similarity 198, member B
FBLN1 fibulin 1
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDE1 glycerophosphodiester phosphodiesterase 1
GNS glucosamine (N-acetyl)-6-sulfatase
GPC3 glypican 3
GPC4 glypican 4
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSN gelsolin
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
GUSBP3 glucuronidase, beta pseudogene 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IRS1 insulin receptor substrate 1
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMP2 lysosomal-associated membrane protein 2
LOX lysyl oxidase
MAN2B1 mannosidase, alpha, class 2B, member 1
MAN2B2 mannosidase, alpha, class 2B, member 2
MAP1B microtubule-associated protein 1B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
METRN meteorin, glial cell differentiation regulator
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MPHOSPH8 M-phase phosphoprotein 8
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NQO2 NAD(P)H dehydrogenase, quinone 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRP1 neuropilin 1
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLVAP plasmalemma vesicle associated protein
PRDX2 peroxiredoxin 2
PRKCB protein kinase C, beta
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
REEP1 receptor accessory protein 1
RHOBTB3 Rho-related BTB domain containing 3
RNF130 ring finger protein 130
RTN1 reticulon 1
S100A4 S100 calcium binding protein A4
SCARB2 scavenger receptor class B, member 2
SERINC5 serine incorporator 5
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLIT2 slit homolog 2 (Drosophila)
SOCS2 suppressor of cytokine signaling 2
SOX11 SRY (sex determining region Y)-box 11
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TCF4 transcription factor 4
TCTN1 tectonic family member 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM47 transmembrane protein 47
TMEM59 transmembrane protein 59
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
WSB1 WD repeat and SOCS box containing 1
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ACSL3 acyl-CoA synthetase long-chain family member 3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CACYBP calcyclin binding protein
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CENPF centromere protein F, 350/400kDa
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLTC clathrin, heavy chain (Hc)
CSNK1D casein kinase 1, delta
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFHD1 EF-hand domain family, member D1
EIF4A3 eukaryotic translation initiation factor 4A3
ELF5 E74-like factor 5 (ets domain transcription factor)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FASN fatty acid synthase
FBL fibrillarin
FCGBP Fc fragment of IgG binding protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLUL glutamate-ammonia ligase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GUSBP11 glucuronidase, beta pseudogene 11
HEATR1 HEAT repeat containing 1
HMGB2 high mobility group box 2
HSPA8 heat shock 70kDa protein 8
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ISG20 interferon stimulated exonuclease gene 20kDa
IVNS1ABP influenza virus NS1A binding protein
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KIF13B kinesin family member 13B
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LRRC8D leucine rich repeat containing 8 family, member D
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
NFIB nuclear factor I/B
NMI N-myc (and STAT) interactor
NOL11 nucleolar protein 11
NUP50 nucleoporin 50kDa
NUP85 nucleoporin 85kDa
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PIP prolactin-induced protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PSD3 pleckstrin and Sec7 domain containing 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTX3 pentraxin 3, long
RAE1 ribonucleic acid export 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS2 regulator of G-protein signaling 2
RNPS1 RNA binding protein S1, serine-rich domain
RRP1B ribosomal RNA processing 1B
S100A7 S100 calcium binding protein A7
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC43A3 solute carrier family 43, member 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D4 TBC1 domain family, member 4
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRAPPC3 trafficking protein particle complex 3
TRIM2 tripartite motif containing 2
TXLNA taxilin alpha
U2AF1 U2 small nuclear RNA auxiliary factor 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
USP22 ubiquitin specific peptidase 22
WDR45B WD repeat domain 45B
XBP1 X-box binding protein 1
Funding