BRD-K13662825_dinaciclib_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K13662825_dinaciclib_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL4 adhesion G protein-coupled receptor L4
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
AK4 adenylate kinase 4
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALG8 ALG8, alpha-1,3-glucosyltransferase
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AOC3 amine oxidase, copper containing 3
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ASRGL1 asparaginase like 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATXN1 ataxin 1
BACE2 beta-site APP-cleaving enzyme 2
BICD1 bicaudal D homolog 1 (Drosophila)
C1QTNF3 C1q and tumor necrosis factor related protein 3
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCL19 chemokine (C-C motif) ligand 19
CD200 CD200 molecule
CD48 CD48 molecule
CDC42 cell division cycle 42
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CKLF chemokine-like factor
CLU clusterin
CNTNAP2 contactin associated protein-like 2
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CTSB cathepsin B
CTSC cathepsin C
CTSD cathepsin D
CTSO cathepsin O
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYBA cytochrome b-245, alpha polypeptide
DACH1 dachshund family transcription factor 1
DICER1 dicer 1, ribonuclease type III
DMTF1 cyclin D binding myb-like transcription factor 1
DYNLT3 dynein, light chain, Tctex-type 3
ECHDC2 enoyl CoA hydratase domain containing 2
ECM1 extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ENO2 enolase 2 (gamma, neuronal)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGFR4 fibroblast growth factor receptor 4
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD2 FXYD domain containing ion transport regulator 2
FYB FYN binding protein
G0S2 G0/G1 switch 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATAD1 GATA zinc finger domain containing 1
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTO1 glutathione S-transferase omega 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIP1 huntingtin interacting protein 1
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOOK2 hook microtubule-tethering protein 2
HSPB8 heat shock 22kDa protein 8
IDO1 indoleamine 2,3-dioxygenase 1
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LOX lysyl oxidase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METRN meteorin, glial cell differentiation regulator
MSX1 msh homeobox 1
MXRA5 matrix-remodelling associated 5
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZK1IP1 PDZK1 interacting protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLIN1 perilipin 1
PLVAP plasmalemma vesicle associated protein
PPAP2A phosphatidic acid phosphatase type 2A
PSENEN presenilin enhancer gamma secretase subunit
RABGAP1L RAB GTPase activating protein 1-like
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
SCG2 secretogranin II
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLIT2 slit homolog 2 (Drosophila)
SORBS1 sorbin and SH3 domain containing 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON1 spondin 1, extracellular matrix protein
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULF1 sulfatase 1
TCF4 transcription factor 4
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM14B transmembrane protein 14B
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TRA2A transformer 2 alpha homolog (Drosophila)
TRAC T cell receptor alpha constant
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
VWA5A von Willebrand factor A domain containing 5A
WARS tryptophanyl-tRNA synthetase
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ANXA3 annexin A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CCNB2 cyclin B2
CD164 CD164 molecule, sialomucin
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
DDIT4 DNA-damage-inducible transcript 4
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
ELF5 E74-like factor 5 (ets domain transcription factor)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBL fibrillarin
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HEATR1 HEAT repeat containing 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLL1 immunoglobulin lambda-like polypeptide 1
IVNS1ABP influenza virus NS1A binding protein
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LRRC8D leucine rich repeat containing 8 family, member D
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYBPC1 myosin binding protein C, slow type
NBPF10 neuroblastoma breakpoint family, member 10
NFIB nuclear factor I/B
NMI N-myc (and STAT) interactor
NOP56 NOP56 ribonucleoprotein
OPN3 opsin 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PIP prolactin-induced protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSD3 pleckstrin and Sec7 domain containing 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBM38 RNA binding motif protein 38
RGS2 regulator of G-protein signaling 2
S100A7 S100 calcium binding protein A7
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC43A3 solute carrier family 43, member 3
SOX4 SRY (sex determining region Y)-box 4
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCP1 t-complex 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
TUBB3 tubulin, beta 3 class III
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L1 ZFP36 ring finger protein-like 1
Funding