BRD-K13662825_dinaciclib_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-K13662825_dinaciclib_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACVR1 activin A receptor, type I
ADCY1 adenylate cyclase 1 (brain)
ADD3 adducin 3 (gamma)
AIDA axin interactor, dorsalization associated
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AOX1 aldehyde oxidase 1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
CADM1 cell adhesion molecule 1
CD46 CD46 molecule, complement regulatory protein
CERS6 ceramide synthase 6
CES1 carboxylesterase 1
CFI complement factor I
CHN2 chimerin 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLU clusterin
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CPB1 carboxypeptidase B1 (tissue)
CPVL carboxypeptidase, vitellogenic-like
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSB cathepsin B
CTSC cathepsin C
CTSO cathepsin O
CTSS cathepsin S
CXADR coxsackie virus and adenovirus receptor
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DLX2 distal-less homeobox 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
ENO1 enolase 1, (alpha)
ERBB4 erb-b2 receptor tyrosine kinase 4
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GLIPR1 GLI pathogenesis-related 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8B golgin A8 family, member B
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
HLF hepatic leukemia factor
HMGN4 high mobility group nucleosomal binding domain 4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
IQCG IQ motif containing G
ISYNA1 inositol-3-phosphate synthase 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAMP3 lysosomal-associated membrane protein 3
LPPR1 lipid phosphate phosphatase-related protein type 1
LYPLA1 lysophospholipase I
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MBNL2 muscleblind-like splicing regulator 2
MCUR1 mitochondrial calcium uniporter regulator 1
MDFIC MyoD family inhibitor domain containing
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
NLRP2 NLR family, pyrin domain containing 2
NTS neurotensin
ORM1 orosomucoid 1
OSBPL8 oxysterol binding protein-like 8
P4HB prolyl 4-hydroxylase, beta polypeptide
PLBD1 phospholipase B domain containing 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RELN reelin
RHOB ras homolog family member B
SCARB2 scavenger receptor class B, member 2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
STC1 stanniocalcin 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF4 transcription factor 4
TGFB1 transforming growth factor, beta 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM14B transmembrane protein 14B
TXNIP thioredoxin interacting protein
URI1 URI1, prefoldin-like chaperone
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADORA2B adenosine A2b receptor
AHNAK2 AHNAK nucleoprotein 2
ARMCX6 armadillo repeat containing, X-linked 6
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
C14ORF2 chromosome 14 open reading frame 2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CX3CR1 chemokine (C-X3-C motif) receptor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
GPATCH8 G patch domain containing 8
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IL1R2 interleukin 1 receptor, type II
ITPKB inositol-trisphosphate 3-kinase B
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MED6 mediator complex subunit 6
MKNK2 MAP kinase interacting serine/threonine kinase 2
MRPS2 mitochondrial ribosomal protein S2
MUC5B mucin 5B, oligomeric mucus/gel-forming
NUP62 nucleoporin 62kDa
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PRKCDBP protein kinase C, delta binding protein
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RET ret proto-oncogene
RGS2 regulator of G-protein signaling 2
RNPS1 RNA binding protein S1, serine-rich domain
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC35F2 solute carrier family 35, member F2
SPRR1A small proline-rich protein 1A
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRIM29 tripartite motif containing 29
TUBA4A tubulin, alpha 4a
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UBE3B ubiquitin protein ligase E3B
USP22 ubiquitin specific peptidase 22
USP3 ubiquitin specific peptidase 3
VGLL4 vestigial-like family member 4
YBX3 Y box binding protein 3
ZHX2 zinc fingers and homeoboxes 2
Funding