BRD-K13810148_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

309 genes differentially expressed following the BRD-K13810148_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD3 abhydrolase domain containing 3
ACO1 aconitase 1, soluble
ACOT7 acyl-CoA thioesterase 7
AGFG2 ArfGAP with FG repeats 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALAD aminolevulinate dehydratase
ALDOC aldolase C, fructose-bisphosphate
ANOS1 anosmin 1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
AVPI1 arginine vasopressin-induced 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF16 chromosome 9 open reading frame 16
CALCOCO2 calcium binding and coiled-coil domain 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND3 cyclin D3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L2 chitinase 3-like 2
CHN2 chimerin 2
CKB creatine kinase, brain
CLDN10 claudin 10
CLIC5 chloride intracellular channel 5
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CPD carboxypeptidase D
CRLF1 cytokine receptor-like factor 1
CTSA cathepsin A
CYFIP2 cytoplasmic FMR1 interacting protein 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DGKA diacylglycerol kinase, alpha 80kDa
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL2 dihydropyrimidinase-like 2
DUSP5 dual specificity phosphatase 5
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETHE1 ethylmalonic encephalopathy 1
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FAM117A family with sequence similarity 117, member A
FBLN5 fibulin 5
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FN1 fibronectin 1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
GOLGA7 golgin A7
GRK5 G protein-coupled receptor kinase 5
GRN granulin
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HDAC1 histone deacetylase 1
HECA headcase homolog (Drosophila)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HRSP12 heat-responsive protein 12
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFT57 intraflagellar transport 57
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IQCG IQ motif containing G
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITM2C integral membrane protein 2C
KCTD5 potassium channel tetramerization domain containing 5
KLHL24 kelch-like family member 24
LCK LCK proto-oncogene, Src family tyrosine kinase
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LPXN leupaxin
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LTA4H leukotriene A4 hydrolase
MAGEB2 melanoma antigen family B2
MALL mal, T-cell differentiation protein-like
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MBNL2 muscleblind-like splicing regulator 2
MDH1 malate dehydrogenase 1, NAD (soluble)
MGST3 microsomal glutathione S-transferase 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLF1 myeloid leukemia factor 1
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MVP major vault protein
MXRA7 matrix-remodelling associated 7
NCAM1 neural cell adhesion molecule 1
NLRP2 NLR family, pyrin domain containing 2
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NT5E 5'-nucleotidase, ecto (CD73)
OAT ornithine aminotransferase
OPTN optineurin
OSBPL8 oxysterol binding protein-like 8
PAIP2B poly(A) binding protein interacting protein 2B
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK5 proprotein convertase subtilisin/kexin type 5
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PFKM phosphofructokinase, muscle
PLA2G15 phospholipase A2, group XV
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PNMA2 paraneoplastic Ma antigen 2
POR P450 (cytochrome) oxidoreductase
PRAF2 PRA1 domain family, member 2
PRKCA protein kinase C, alpha
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS2 regulator of G-protein signaling 2
ROGDI rogdi homolog (Drosophila)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGCE sarcoglycan, epsilon
SKAP2 src kinase associated phosphoprotein 2
SKP1 S-phase kinase-associated protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SPAG9 sperm associated antigen 9
SPTAN1 spectrin, alpha, non-erythrocytic 1
SST somatostatin
STAR steroidogenic acute regulatory protein
STK17A serine/threonine kinase 17a
STOM stomatin
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBPL1 TBP-like 1
TGFA transforming growth factor, alpha
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM41B transmembrane protein 41B
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAK2 trafficking protein, kinesin binding 2
TSPAN7 tetraspanin 7
TUBA4A tubulin, alpha 4a
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AKAP8 A kinase (PRKA) anchor protein 8
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARID1A AT rich interactive domain 1A (SWI-like)
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND1 cyclin D1
CD58 CD58 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CKAP4 cytoskeleton-associated protein 4
CLIC2 chloride intracellular channel 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL4A6 collagen, type IV, alpha 6
CTBP1 C-terminal binding protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
DCLK1 doublecortin-like kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
EPCAM epithelial cell adhesion molecule
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FHL2 four and a half LIM domains 2
FOXA1 forkhead box A1
FOXM1 forkhead box M1
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GREB1 growth regulation by estrogen in breast cancer 1
GSAP gamma-secretase activating protein
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IGF1R insulin-like growth factor 1 receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRS1 insulin receptor substrate 1
KANK1 KN motif and ankyrin repeat domains 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KYNU kynureninase
LMNB1 lamin B1
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MLPH melanophilin
MPPED2 metallophosphoesterase domain containing 2
MREG melanoregulin
MRPS2 mitochondrial ribosomal protein S2
MSL1 male-specific lethal 1 homolog (Drosophila)
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
MZT2A mitotic spindle organizing protein 2A
NBN nibrin
NOL11 nucleolar protein 11
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCDH7 protocadherin 7
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1 PDZ domain containing 1
PHIP pleckstrin homology domain interacting protein
PLK1 polo-like kinase 1
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
POSTN periostin, osteoblast specific factor
PRR7 proline rich 7 (synaptic)
QKI QKI, KH domain containing, RNA binding
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SENP6 SUMO1/sentrin specific peptidase 6
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX17 SRY (sex determining region Y)-box 17
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX2 T-box 2
TCERG1 transcription elongation regulator 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TPBG trophoblast glycoprotein
TTC39A tetratricopeptide repeat domain 39A
TUSC3 tumor suppressor candidate 3
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF512B zinc finger protein 512B