BRD-K14027855_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K14027855_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C5AR1 complement component 5a receptor 1
CA1 carbonic anhydrase I
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CKB creatine kinase, brain
CLDN8 claudin 8
CSRP1 cysteine and glycine-rich protein 1
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
F3 coagulation factor III (thromboplastin, tissue factor)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GLRX glutaredoxin (thioltransferase)
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
JCHAIN joining chain of multimeric IgA and IgM
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LPAR1 lysophosphatidic acid receptor 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
N4BP2L1 NEDD4 binding protein 2-like 1
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NRIP1 nuclear receptor interacting protein 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPP1 selenoprotein P, plasma, 1
SERTAD2 SERTA domain containing 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMYD2 SET and MYND domain containing 2
STC2 stanniocalcin 2
TNIP1 TNFAIP3 interacting protein 1
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
BAMBI BMP and activin membrane-bound inhibitor
C7 complement component 7
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
HSPA1A heat shock 70kDa protein 1A
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LAMP5 lysosomal-associated membrane protein family, member 5
PPARG peroxisome proliferator-activated receptor gamma
RPP25 ribonuclease P/MRP 25kDa subunit
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2