BRD-K14618467_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K14618467_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ANXA10 annexin A10
ARMCX1 armadillo repeat containing, X-linked 1
ASCL1 achaete-scute family bHLH transcription factor 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CPE carboxypeptidase E
CXCL9 chemokine (C-X-C motif) ligand 9
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM131A family with sequence similarity 131, member A
FBXL12 F-box and leucine-rich repeat protein 12
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
GPNMB glycoprotein (transmembrane) nmb
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXD1 homeobox D1
HSPA13 heat shock protein 70kDa family, member 13
INSIG1 insulin induced gene 1
KRT14 keratin 14, type I
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
MXRA5 matrix-remodelling associated 5
PBX1 pre-B-cell leukemia homeobox 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RPL36 ribosomal protein L36
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
STXBP2 syntaxin binding protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TRPS1 trichorhinophalangeal syndrome I
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRG2 adhesion G protein-coupled receptor G2
AIM1 absent in melanoma 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AXL AXL receptor tyrosine kinase
BEX1 brain expressed, X-linked 1
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CCND1 cyclin D1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK6 cyclin-dependent kinase 6
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHMP4A charged multivesicular body protein 4A
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CTGF connective tissue growth factor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHA2 EPH receptor A2
FBN1 fibrillin 1
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GPRC5A G protein-coupled receptor, class C, group 5, member A
GUSB glucuronidase, beta
HBB hemoglobin, beta
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP3 insulin-like growth factor binding protein 3
ITGA6 integrin, alpha 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LEF1 lymphoid enhancer-binding factor 1
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MNAT1 MNAT CDK-activating kinase assembly factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NIT2 nitrilase family, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PCOLCE procollagen C-endopeptidase enhancer
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA1A phospholipase A1 member A
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PRKCA protein kinase C, alpha
PRSS23 protease, serine, 23
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RER1 retention in endoplasmic reticulum sorting receptor 1
S100P S100 calcium binding protein P
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SMAGP small cell adhesion glycoprotein
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE2A ubiquitin-conjugating enzyme E2A